Most Read Articles
05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

Roshini Claire Anthony, 5 days ago

Switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) did not result in worsening renal function or bone mineral density (BMD) in Asian patients with chronic hepatitis B virus (HBV) infection, according to a small real-world prospective study.

23 Feb 2021
Patients with multiple endocrine neoplasia type 1 (MEN1) are at greater risk of experiencing venous thromboembolism (VTE), suggests a recent study.
Roshini Claire Anthony, 3 days ago

Critical or severe COVID-19 disease could raise the risk of negative perinatal outcomes in pregnant women, according to an observational study from the US.

Tobacco linked to global trends in bladder cancer

10 Dec 2020

The incidence and associated mortality rates of bladder cancer worldwide appear to be correlated with the rates of tobacco use, a recent study has found.

Researchers retrieved data on bladder cancer rates from three sources: the GLOBOCAN database, the Cancer Incidence in Five Countries, and the WHO mortality databases. Tobacco use was determined through information from the WHO Global Health Observatory.

In 2018, the researchers found 549,393 new cases of bladder cancer leading to 199,922 related deaths. These rates varied widely between sexes and across geographical regions. In men, for instance, age-standardized rates (ASRs) of bladder cancer ranged from as low as 1.3 per 100,000 in middle Africa to a maximum of 26.5 per 100,00 in Southern Europe.

Sex-stratified bladder cancer mortality rates were 3.2 and 0.9 per 100,000 in men and women, respectively.

Notably, researchers detected a positive correlation between tobacco use and bladder cancer incidence (r, 0.20) and mortality (r, 0.38) in men. This was also true in women, but the effect of tobacco use on cancer incidence was stronger (r, 0.67), while its influence on associated mortality was weaker (r, 0.22).

This was confirmed through multivariable linear regression analysis of bladder cancer incidence (men: coefficient, 0.152, 95 percent confidence interval [CI], 0.017–0.286; p=0.027; women: coefficient, 0.116, 95 percent CI, 0.078–0.154; p<0.001). Mortality, on the other hand, was only significantly associated with tobacco use in men (coefficient, 0.067, 95 percent CI, 0.025–0.108; p=0.002).

“Tobacco use was significantly associated with both bladder cancer incidence and mortality. Hence, a global effort to promote smoking cessation is extremely important to reduce bladder cancer incidence and mortality in the long run,” the researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

Roshini Claire Anthony, 5 days ago

Switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) did not result in worsening renal function or bone mineral density (BMD) in Asian patients with chronic hepatitis B virus (HBV) infection, according to a small real-world prospective study.

23 Feb 2021
Patients with multiple endocrine neoplasia type 1 (MEN1) are at greater risk of experiencing venous thromboembolism (VTE), suggests a recent study.
Roshini Claire Anthony, 3 days ago

Critical or severe COVID-19 disease could raise the risk of negative perinatal outcomes in pregnant women, according to an observational study from the US.