Most Read Articles
Dr. Joseph Delano Fule Robles, 14 Nov 2017

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

14 Nov 2017
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
6 days ago
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
6 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.

TNFR 1, 2 linked to all-cause, cardiovascular mortality in haemodialysis

12 Mar 2017

The risk of all-cause and cardiovascular mortality among end-stage renal disease patients receiving haemodialysis may be associated with increased levels of the circulating tumour necrosis factor receptors (TNFR), a new study reports.

The study included 319 patients undergoing haemodialysis. Only those who were clinically stable and with baseline serum data were included; those who had advanced dementia, were hospitalized two months prior or received haemodialysis for <1 month were excluded.

The primary outcomes were cardiovascular and all-cause mortality. These included mortalities from myocardial infarction, arrhythmia, stroke and congestive heart failure. Enzyme-linked immunosorbent assay was used to measure TNFR 1, 2 and total TNF-α levels.

Of the participants, 60.8 percent were male and 50.2 percent had diabetes. After a median follow-up period of 53 months, 72.4 percent of the participants remained alive. Of those who died, 45.5 percent died because of cardiovascular diseases.

Univariate analysis showed that all-cause mortality was significantly associated with both TNFRs (TNFR1: hazard ratio [HR], 2.42; 95 percent CI, 1.58 to 3.70; p<0.0001; TNFR2: HR, 2.70; 1.77 to 4.13; p<0.0001) but not with TNF-α. This trend remained significant even after controlling for other variables like age, blood pressure and prior cardiovascular diseases (TNFR1: HR, 2.34; 1.50 to 3.64; p<0.0001; TNFR2: HR, 2.13; 1.38 to 3.29; p<0.0001).

Only TNFR1 showed significant association with cardiovascular mortality after controlling for variables (HR, 2.15; 1.13 to 4.10; p=0.02).

The findings thus show a correlation between all-cause and cardiovascular mortality and circulating TNFRs in end-stage renal disease patients undergoing haemodialysis.

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Most Read Articles
Dr. Joseph Delano Fule Robles, 14 Nov 2017

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

14 Nov 2017
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
6 days ago
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
6 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.