Most Read Articles
Elaine Soliven, 27 Sep 2017
A second dose of kisspeptin-54 improves oocyte yield in women at high risk of ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) treatment, according to a recent study.
23 Oct 2017
Pearl Toh spoke with Dr Teh Ming Ming, senior consultant at the Department of Endocrinology, Singapore General Hospital (SGH), on the major challenges of diagnosing and managing diabetes in primary care, in conjunction with the World Diabetes Day on 14 November. Awareness of the symptoms of diabetes is important, and patients should be empowered to manage their conditions.
Rachel Soon, Yesterday

Pharmacists can and should utilize their positions within communities to provide access to an extended range of healthcare services, says an expert.

01 Aug 2017
New drug applications approved by US FDA as of 1 - 15 June 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

TNF inhibitors may slightly increase risk of developing severe extra-articular RA

10 Jul 2017

Patients treated with tumour necrosis factor (TNF) inhibitors are marginally prone to develop severe extra-articular rheumatoid arthritis (ExRA), a study suggests. In addition, rheumatoid factor (RF)-positive patients with disabling disease of long duration are at an increased risk of developing severe ExRA.

Researchers recruited a dynamic community-based cohort of patients with RA (n=1,977) to assess whether treatment with TNF inhibitors affected the risk of developing severe ExRA manifestations, as well as to study potential predictors for developing ExRA. They reviewed clinical records and identified cases of severe ExRA. Information on exposure to TNF inhibitors was obtained from a regional register.

Analysis of exposure to TNF inhibitors was done in a time-dependent fashion. Additionally, researchers compared the incidence of severe ExRA in exposed patients with the incidence in those who were unexposed. Cox regression models were used to evaluate possible predictors of severe ExRA.

A total of 17 patients had new onset of severe ExRA during treatment with TNF inhibitors in 2,400 person-years at risk (0.71/100; 95 percent CI, 0.41 to 1.13) compared with 104 in 15,599 person-years (0.67/100; 0.54 to 0.81) in those without TNF inhibitors, corresponding to an incidence rate ratio of 1.06 (0.60 to 1.78).

Anti-TNF‒treated patients had a hazard ratio for ExRA of 1.21 (1.02 to 1.43), adjusted for age and sex; the findings were similar in models adjusted for time-dependent Health Assessment Questionnaire and propensity for anti-TNF treatment.

The predictors for ExRA were male sex, positive RF, long disease duration and greater disability, according to researchers.

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Most Read Articles
Elaine Soliven, 27 Sep 2017
A second dose of kisspeptin-54 improves oocyte yield in women at high risk of ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) treatment, according to a recent study.
23 Oct 2017
Pearl Toh spoke with Dr Teh Ming Ming, senior consultant at the Department of Endocrinology, Singapore General Hospital (SGH), on the major challenges of diagnosing and managing diabetes in primary care, in conjunction with the World Diabetes Day on 14 November. Awareness of the symptoms of diabetes is important, and patients should be empowered to manage their conditions.
Rachel Soon, Yesterday

Pharmacists can and should utilize their positions within communities to provide access to an extended range of healthcare services, says an expert.

01 Aug 2017
New drug applications approved by US FDA as of 1 - 15 June 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.