Most Read Articles
Rachel Soon, 26 Jun 2018

MIMS Pharmacist presents an overview of phosphatidylcholine's physiological role, as well as contemporary research on its pharmacology and effects.

Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
Tristan Manalac, 10 Apr 2018
In patients with moderate-to-severe chronic obstructive pulmonary disease (COPD), the drug combination of indacaterol/glycopyrronium (IND/GLY) is more cost-effective than the inhaled combination of salmeterol/fluticasone (SFC), a recent Singapore study has found.
05 Oct 2015
Tigecycline is safe and effective in the treatment of necrotising skin and soft tissue infections due to resistant pathogens in critically ill and antimicrobially pre-treated patients, as reported in a prospective multi-centre non-interventional study.

TNF inhibitors confer benefits for hand osteoarthritis progression

17 Mar 2018

Treatment with tumour necrosis factor inhibitors (TNFi) appears to reduce the risk of radiographic hand osteoarthritis (OA) progression in distal interphalangeal (DIP) joints but not in proximal interphalangeal (PIP) joints for up to 10 years, according to a study.

Researchers examined the radiographs of 262 rheumatoid arthritis (RA) patients (mean age 52 years; 66 percent female) participating in the BeSt study. Radiographs were scored for osteophytes in DIP/PIP joints according to the Osteoarthritis Research Society International atlas (0–3; summed score 0–54) and according to the Kellgren–Lawrence (KL) score (0–4; summed score 0–72) at baseline and at 10-year follow-up.

TNFi treatment was assessed on visits every 3 months and evaluated in relation to hand OA using generalized linear models and generalized estimating equations.

Of the patients, 58 percent received treatment with TNFi, with a median duration of 42 months. At baseline, there were 143 (55 percent) who had hand OA in any IP joint based on the Osteoarthritis Research Society International osteophyte score.

TNFi treatment duration did not influence incidental hand OA on the patient level. However, every month of TNFi treatment reduced the risk (RR) of hand OA progression in DIP joints (relative risk [RR], 0.987; 95 percent CI, 0.978–0.996) but not in PIP joints.

On the joint level, the effect of TNFi treatment on hand OA progression was likewise evident in DIP joints (RR, 0.996; 0.991–1.000) but not in PIP joints. Results for the KL score did not differ with those for osteophyte score.

Although the effect sizes are small, the findings of the present study provide evidence for the influence of tumour necrosis factor-alpha in hand OA pathogenesis, researchers said.

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Most Read Articles
Rachel Soon, 26 Jun 2018

MIMS Pharmacist presents an overview of phosphatidylcholine's physiological role, as well as contemporary research on its pharmacology and effects.

Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
Tristan Manalac, 10 Apr 2018
In patients with moderate-to-severe chronic obstructive pulmonary disease (COPD), the drug combination of indacaterol/glycopyrronium (IND/GLY) is more cost-effective than the inhaled combination of salmeterol/fluticasone (SFC), a recent Singapore study has found.
05 Oct 2015
Tigecycline is safe and effective in the treatment of necrotising skin and soft tissue infections due to resistant pathogens in critically ill and antimicrobially pre-treated patients, as reported in a prospective multi-centre non-interventional study.