Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
5 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

Tislelizumab + chemo exhibits favourable tolerability for gastric cancer, oesophageal SCC

Audrey Abella
14 Feb 2019

The addition of the investigational, humanized IgG4* monoclonal antibody tislelizumab to chemotherapy was generally well-tolerated and generated favourable antitumour activity in patients with advanced gastric/gastroesophageal (G/GEJ) cancer and oesophageal squamous cell carcinoma (SCC), according to data presented at ASCO GI 2019.

Fifteen Chinese participants (median age 59 years, 73 percent male) with histologically or cytologically confirmed HER2**-negative G/GEJ received intravenous (IV) tislelizumab 200 mg, oxaliplatin 130 mg/m² (up to six cycles), and capecitabine 1,000 mg/m² (twice/day; days 1–14). The regimen was administered every 3 weeks (Q3W). Tumour responses were evaluated every 9 weeks in the first year and every 12 weeks thereafter. [ASCO GI 2019, abstract 11]

The most frequent treatment-related adverse event (AE) was asthenia (53 percent), followed by increased aspartate aminotransferase (AST) and nausea (47 percent each), and increased alanine aminotransferase (ALT) and vomiting (40 percent each). Three patients discontinued treatment due to ascites, increased ALT/AST, or elevated total bilirubin. No fatal AEs occurred.

“[The] reported AEs were consistent with the known tolerability profile of [programmed cell death-1] inhibitors in combination with chemotherapy,” said the researchers, adding that the AEs were mostly mild to moderate in severity.

After a median follow-up of 181 days, 47 percent had confirmed partial response while 20 percent had stable disease. Objective response and disease control rates were 47 percent and 80 percent, respectively, translating to favourable antitumour activity, noted the researchers.

In a subanalysis of the same study, 15 participants (median age 61 years, 93 percent male) with inoperable, locally advanced oesophageal SCC received IV tislelizumab 200 mg, cisplatin 80 mg/m² (up to six cycles), and fluorouracil 800 mg/m²/day (up to six cycles; days 1–5) Q3W. [ASCO GI 2019, abstract 14]

Decreased appetite was the most common AE (n=9) followed by nausea, anaemia, and reduction in white blood cell count (n=8, 6, and 6, respectively). One patient experienced grade 5 hepatic dysfunction which, according to the researchers, could be treatment-related. Four patients discontinued treatment due to AEs (grade 3 tracheal fistula, grade 3 lung infection, grade 2 pneumonitis, and grade 3 increase in AST).

These findings highlight the potential of tislelizumab as a therapeutic option for G/GEJ cancer which currently has limited treatment options, with chemotherapy primarily used for unresectable, metastatic HER2-negative cases, noted the researchers. [Lancet 2016;388:2654-2664; World J Gastroenterol 2016;22:4812-4823] “[Taken together,] the safety, tolerability, and antitumour activity observed in this study support continued development of tislelizumab in [this setting],” said the researchers.

 

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
5 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.