Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 5 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.

Timing of RT initiation does not improve long-term outcome in breast cancer

12 Aug 2017

Starting radiation therapy (RT) shortly after breast-conserving surgery (BCS) does not appear to yield improvements in long-term outcome, bringing into question the common position that RT should be initiated as soon as possible following surgery so as to increase treatment efficacy in breast cancer patients, according to a recent study.

The study included two cohorts of women with primary invasive stage I to IIIA breast cancer and treated with BCS+RT. Cohort 1 (n=2,759) excluded patients receiving chemotherapy before RT, and analysis was stratified according to the use of adjuvant systemic therapy (AST). Cohort 2 (n=1,120) comprised patients who received chemotherapy, and analysis was performed by comparing chemotherapy before (BCS-chemotherapy-RT) and after RT (BCS-RT-chemotherapy).

The primary endpoint was disease-free survival (DFS), as estimated using multivariable Cox regression. Locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS) and overall survival (OS) were also evaluated as secondary endpoints.

Cohort 1 showed better DFS and DMFS for a time interval of >55 vs <42 days. Patients who received AST had even higher DFS for >55 days (hazards ratio [HR], 0.60; 95 percent CI, 0.38 to 0.94) and for 42 to 55 days (HR, 0.64; 0.45 to 0.91) than for <42 days. A similar pattern of results was observed for DMFS, whereas timing had no effect on LRRFS and OS.

Among patients without AST, timing showed no association with DFS, DMFS and LLRFS. However, 10-year OS was notably lower for a time interval of 42 to 55 and >55 vs <42 days.

In cohort 2, timing did not influence survival among patients who received BCS-chemotherapy-RT. For those who had BCS-RT-chemotherapy, DMFS was higher for a time interval of >55 than <42 days.

The present data suggest initiating RT as soon as possible after BCS is not necessary as timing does not improve survival rates, researchers said. It is important that patients are informed about this to prevent them from worrying about tumour growth and worse outcomes in case of a longer time interval between BCS and RT.

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Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 5 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.