Most Read Articles
Pearl Toh, 20 Nov 2019
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Participating in a long-distance skiing event may help lower the risk of hypertension, with the number of completed races showing a weak association with the risk, a study has found.
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Target organ damage appears to be more noticeable in patients affected by primary aldosteronism than those affected by arterial hypertension without primary aldosteronism, suggests a study, adding that specific treatment can ease such condition.

Ticagrelor monotherapy noninferior to DAPT plus aspirin in PCI patients

07 Nov 2019

Use of ticagrelor alone among patients who underwent percutaneous coronary intervention (PCI) after 1-month dual antiplatelet therapy (DAPT) has shown noninferiority, but is not superior, to conventional treatment in the prevention of ischaemic events, reports a study. Major bleeding is also comparable between ticagrelor monotherapy and conventional treatment.

A total of 15,991 patients undergoing PCI were randomized to 1-month DAPT followed by 23-month ticagrelor monotherapy or conventional 12-month DAPT followed by 12-month aspirin.

The authors conducted a prespecified ancillary study to assess whether experimental therapy was noninferior, and if met, superior, to conventional treatment for the coprimary efficacy endpoint of all-cause mortality, nonfatal myocardial infarction (MI), nonfatal stroke or urgent target vessel revascularization and superior in preventing BARC (Bleeding Academic Research Consortium) 3 or 5 bleeding (coprimary safety endpoint) at 2 years with a 0.025 significance level to preserve nominal 5 percent alpha error.

Investigator-reported and eventually unreported events of 7,585 patients from the 20 top-enrolling participating sites were resolved by an independent clinical event committee.

The 2-year coprimary efficacy endpoint occurred in 271 (7.14 percent) patients in the ticagrelor group and in 319 (8.41 percent) patients in the conventional group (rate ratio [RR], 95 percent confidence interval [CI], 0.72–0.99), achieving noninferiority of the former (p<0.001) but not superiority (p=0.0465). No between-group difference was seen in the rates of BARC 3 or 5 bleeding (RR, 1.00, 95 percent CI, 0.75–1.33; p=0.986).

There was a time-dependent treatment effect in the ticagrelor group, which correlated with a reduced risk of MI (RR, 0.54, 95 percent CI, 0.33–0.88; p=0.062) and definite stent thrombosis (RR, 014, 0.03–0.63; p=0.007) after 1-year post-PCI.

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Most Read Articles
Pearl Toh, 20 Nov 2019
The trade-off between the risk of ischaemic vs bleeding events may be different between Asian and non-Asian patients, which warrants careful consideration when deciding on the duration of antiplatelet therapy following a percutaneous coronary intervention (PCI), according to a presentation at ESC Asia Congress 2019.
3 days ago
Participating in a long-distance skiing event may help lower the risk of hypertension, with the number of completed races showing a weak association with the risk, a study has found.
06 Sep 2019
Hypertensive adults with lower plasma zinc concentration are at increased risk of haemorrhagic stroke, especially those with higher body mass index or lower plasma copper levels, a study has found.
06 Jan 2020
Target organ damage appears to be more noticeable in patients affected by primary aldosteronism than those affected by arterial hypertension without primary aldosteronism, suggests a study, adding that specific treatment can ease such condition.