Most Read Articles
Roshini Claire Anthony, 3 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

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Tristan Manalac, 25 May 2020
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Ticagrelor cuts MACE, ups bleeding in AMI patients with multivessel disease

24 Apr 2020

While ticagrelor decreases the risk of major adverse cardiovascular events (MACEs) in acute myocardial infarction (AMI) patients with multivessel disease (MVD), it also appears to come with excess bleeding risk, a recent South Korea study has found.

Of the 2,275 enrolled AMI patients with MVD, 1,438 were on clopidogrel while 837 were taking ticagrelor. The primary study endpoint was MACE, defined as nonfatal AMI, target vessel revascularization, ischaemic stroke or cardiac death. Thrombolysis in myocardial infarction (TIMI) major or minor bleeding was a secondary endpoint.

After propensity score matching and over the 2-year follow-up period, the cumulative incidence of MACE was 8.6 percent in the ticagrelor arm. This was lower than that in the clopidogrel group, corresponding to a significant reduction in risk (11.9 percent; hazard ratio [HR], 0.68, 95 percent confidence interval [CI], 0.50–0.94; p=0.018).

On the other hand, TIMI major or minor bleeding events occurred more frequently in patients treated with ticagrelor (10.8 percent vs 4.8 percent), corresponding to a significant excess in risk (HR, 2.51, 95 percent CI, 1.68–3.76; p<0.001).

Overall, the resulting net incidence of clinical events was comparable between groups (11.3 percent vs 13.6 percent; HR, 0.82, 95 percent CI, 0.60–1.11; p=0.195).

Limitations of the present study included its nonrandomized design, limited available data in the registry and the lack of long-term analysis, especially in terms of the effects of ticagrelor, the researchers said. Future studies are needed to validate the current findings.

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Most Read Articles
Roshini Claire Anthony, 3 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

5 days ago
Eating behaviours have been shown to moderate the relationship between cumulated risk factors in the first 1,000 days and adiposity outcomes at 6 years of age, which underscores modifiable behavioural targets for interventions, reports a study.
Stephen Padilla, 4 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Tristan Manalac, 25 May 2020
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.