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Three-month height predicts 2-year overweight, obesity in infants small for gestational age

13 Sep 2018

In infants that are small for gestational age (SGA), stunted height at 3 months appears to predict overweight and obesity at 2 years, a recent study has found.

Researchers enrolled 468 SGA infants (mean gestational age 39.49±0.98 weeks; 248 females), in whom the mean height and weight at 3 months were 60.69±1.88 cm and 6.39±0.65 kg, respectively. As a comparison group, 4,642 appropriate for gestational age infants (mean gestational age 39.28±1.06 weeks; 2,135 females) were also enrolled.

At 2 years, 432 of the 468 SGA infants (92.3 percent) demonstrated at least –2 standard deviation scores in height and were determined to have completed height catch up. At birth, infants in the catch-up and noncatch-up groups were comparable in length (49.28±1.80 vs 48.42±2.68 cm; p=0.058), but mean birth weight was significantly lower in the latter group (2.63±0.23 vs 2.45±0.27 kg; p<0.001).

Weight at 3 months became comparable between the two groups (noncatch-up vs catch-up: 6.17±0.91 vs 6.41±0.62 kg; p=0.073), while infants in the catch-up group grew significantly taller (61.10±1.71 vs 59.31±2.84 cm; p<0.001).

After 2 years, mean body mass index was statistically similar between groups (16.20 vs 16.25 kg/m2; p=0.496), but infants in the catch-up group were significantly heavier (12.56±0.68 vs 11.37±0.96 kg; p<0.001) and taller (87.97±1.36 vs 82.88±1.39 cm; p<0.001) than those in the noncatch-up group.

Multivariate logistic regression indicated that the height at 3 months was an independent predictor for catch-up growth at 2 years (odds ratio, 1.621; 95 percent CI, 1.284–2.045; p<0.001).

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Most Read Articles
15 hours ago
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
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