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Three-month height predicts 2-year overweight, obesity in infants small for gestational age

13 Sep 2018

In infants that are small for gestational age (SGA), stunted height at 3 months appears to predict overweight and obesity at 2 years, a recent study has found.

Researchers enrolled 468 SGA infants (mean gestational age 39.49±0.98 weeks; 248 females), in whom the mean height and weight at 3 months were 60.69±1.88 cm and 6.39±0.65 kg, respectively. As a comparison group, 4,642 appropriate for gestational age infants (mean gestational age 39.28±1.06 weeks; 2,135 females) were also enrolled.

At 2 years, 432 of the 468 SGA infants (92.3 percent) demonstrated at least –2 standard deviation scores in height and were determined to have completed height catch up. At birth, infants in the catch-up and noncatch-up groups were comparable in length (49.28±1.80 vs 48.42±2.68 cm; p=0.058), but mean birth weight was significantly lower in the latter group (2.63±0.23 vs 2.45±0.27 kg; p<0.001).

Weight at 3 months became comparable between the two groups (noncatch-up vs catch-up: 6.17±0.91 vs 6.41±0.62 kg; p=0.073), while infants in the catch-up group grew significantly taller (61.10±1.71 vs 59.31±2.84 cm; p<0.001).

After 2 years, mean body mass index was statistically similar between groups (16.20 vs 16.25 kg/m2; p=0.496), but infants in the catch-up group were significantly heavier (12.56±0.68 vs 11.37±0.96 kg; p<0.001) and taller (87.97±1.36 vs 82.88±1.39 cm; p<0.001) than those in the noncatch-up group.

Multivariate logistic regression indicated that the height at 3 months was an independent predictor for catch-up growth at 2 years (odds ratio, 1.621; 95 percent CI, 1.284–2.045; p<0.001).

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Most Read Articles
Roshini Claire Anthony, 4 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Elvira Manzano, 5 days ago
Treatment with two investigational, oral JAK inhibitors may be beneficial in individuals with moderate‐to‐severe alopecia areata (spot baldness), an autoimmune disease that can cause a lot of anxiety, according to an ongoing phase II study.
3 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.