Most Read Articles
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Teng Sung Shin, Joyce Lam Ching Mei, 03 Sep 2018
Bleeding disorders in children can be divided into acquired and congenital conditions, with the acquired being far more common than the congenital. Clinical bleeding manifestations can vary in severity. Identifying the root cause early is crucial to control and halt bleeding as well as to prevent the risk of future bleeding in a vulnerable age group. This can be achieved by a thorough and salient history, physical evaluation, and appropriate investigations. This review will describe the common causes of bleeding disorders in children and will suggest an approach to the workup and diagnosis of such disorders.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.

Thiazolidinediones do not lower AF incidence in patients with diabetes, coronary disease

12 Jul 2018
Studies have shown that in general, about 40% of patients are non-adherent to their medication.

Use of thiazolidinediones does not lead to a significant reduction in incidence of atrial fibrillation (AF) among patients with diabetes and coronary disease, a recent study has found.

Of the 2,319 patients enrolled in the study, 1,160 were assigned to the insulin-sensitization strategy and 1,159 to the insulin-provision strategy. A total of 90 patients (3.9 percent) developed new-onset AF during a median follow-up of 4.2 years.

The intention-to-treat analysis demonstrated an AF incidence of 8.7 per 1,000 person-years in patients assigned to insulin sensitization vs 9.5 in those assigned to insulin provision (hazard ratio [HR], 0.91; 95 percent CI, 0.60–1.38; p=0.66).

On the other hand, the incidence rate per 1,000 person-years in a time-varying exposure analysis was 7.2 for patients exposed to thiazolidinediones and 9.7 for those who were not (adjusted HR, 0.80; 0.33–1.94; p=0.62). The HR in a subset of patients matched on propensity to receive thiazolidinediones was 0.75 (0.43–1.30; p=0.30).

A 2008 study showed that the glycaemic efficacy of thiazolidinediones and metformin were similar, but adverse effects and higher costs made the former less appealing for initial therapy. [Ann Pharmacother 2008;42:1466-1474]

To examine whether insulin-sensitizing therapy (thiazolidinediones or metformin) reduced the risk of developing AF vs insulin-providing therapy (insulin, sulphonylurea or meglitinide), the authors enrolled patients with type 2 diabetes and documented coronary artery disease. All patients were randomly assigned to insulin-sensitizing or insulin-providing therapy.

“Thiazolidinediones are insulin sensitizers that also decrease the inflammatory response,” the authors said. “Because inflammation is a risk factor for AF, we hypothesized that treating diabetes with thiazolidinediones might decrease the risk of developing AF.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacist - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Teng Sung Shin, Joyce Lam Ching Mei, 03 Sep 2018
Bleeding disorders in children can be divided into acquired and congenital conditions, with the acquired being far more common than the congenital. Clinical bleeding manifestations can vary in severity. Identifying the root cause early is crucial to control and halt bleeding as well as to prevent the risk of future bleeding in a vulnerable age group. This can be achieved by a thorough and salient history, physical evaluation, and appropriate investigations. This review will describe the common causes of bleeding disorders in children and will suggest an approach to the workup and diagnosis of such disorders.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.