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Thiazide, thiazide-like diuretics up risk of skin cancer

25 Sep 2019

Thiazide and thiazide-like diuretics carry a photosensitizing potential and may increase the risk of skin cancer, a recent study has found.

Resonating structural components, such as sulfonamide groups, were found in commonly used thiazide and thiazide-like diuretics, which contributed to the photosensitizing activity of these drugs.

This narrative review included 13 observational (nine case–control; four cohort) studies that assessed the association between use of different thiazide or thiazide-like diuretics and risk of several skin cancer types. Nine studies revealed positive associations ranging from 3-percent increased risk for bendroflumethiazide and basal cell carcinoma to 311-percent increased risk for thiazide diuretics and squamous cell carcinoma.

However, there were significant design-related methodological limitations found in all studies, including potential confounding by indication, detection bias and time-window bias.

“Well-designed observational studies are needed to provide more solid evidence on this possible association,” the authors said.

This study examined the chemical structures and photosensitizing potential of selected thiazide and thiazide-like diuretics. The authors searched PubMed up to December 2018 for observational studies evaluating the association between use of thiazide or thiazide-like diuretics and risk of skin cancer. Study quality was evaluated for major methodological biases.

“Thiazide diuretics and particularly hydrochlorothiazide were recently linked to an increased risk of skin cancer, which was attributed to the photosensitizing properties of these drugs,” the authors said. “Given the widespread use of thiazide diuretics, a potential skin cancer promoting effect would impose an important public health concern.”

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Most Read Articles
Pearl Toh, 10 Oct 2019
Adding a LAMA* to the double combination therapy of ICS** plus LABA*** in a single inhaler improves lung function and reduces exacerbations in patients whose asthma is inadequately controlled with the combination treatment, according to the TRIMARAN and TRIGGER# studies presented at ERS 2019.
23 hours ago
Environmental quality and exposure to pollution may play a small part in the development of metabolic diseases, such as diabetes, a new study has found.
Tristan Manalac, 2 days ago
Sleep deprivation impairs adolescents’ long-term retention of classroom material, according to a recent Singapore study.
4 days ago
Eating alone may help in weight management as findings of a recent study suggest that eating with friends lead to higher food intake.