Most Read Articles
14 Feb 2020
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
Stephen Padilla, 13 Feb 2020
A pharmacist intervention appears to be effective in lowering and preventing the incidence of prescribing errors of investigational drugs in oncology clinical trials, a recent study has shown.

Thiazide, thiazide-like diuretics up risk of skin cancer

25 Sep 2019

Thiazide and thiazide-like diuretics carry a photosensitizing potential and may increase the risk of skin cancer, a recent study has found.

Resonating structural components, such as sulfonamide groups, were found in commonly used thiazide and thiazide-like diuretics, which contributed to the photosensitizing activity of these drugs.

This narrative review included 13 observational (nine case–control; four cohort) studies that assessed the association between use of different thiazide or thiazide-like diuretics and risk of several skin cancer types. Nine studies revealed positive associations ranging from 3-percent increased risk for bendroflumethiazide and basal cell carcinoma to 311-percent increased risk for thiazide diuretics and squamous cell carcinoma.

However, there were significant design-related methodological limitations found in all studies, including potential confounding by indication, detection bias and time-window bias.

“Well-designed observational studies are needed to provide more solid evidence on this possible association,” the authors said.

This study examined the chemical structures and photosensitizing potential of selected thiazide and thiazide-like diuretics. The authors searched PubMed up to December 2018 for observational studies evaluating the association between use of thiazide or thiazide-like diuretics and risk of skin cancer. Study quality was evaluated for major methodological biases.

“Thiazide diuretics and particularly hydrochlorothiazide were recently linked to an increased risk of skin cancer, which was attributed to the photosensitizing properties of these drugs,” the authors said. “Given the widespread use of thiazide diuretics, a potential skin cancer promoting effect would impose an important public health concern.”

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Most Read Articles
14 Feb 2020
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
Stephen Padilla, 13 Feb 2020
A pharmacist intervention appears to be effective in lowering and preventing the incidence of prescribing errors of investigational drugs in oncology clinical trials, a recent study has shown.