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Product Highlight - Rexulti

16 Sep 2020

REXULTI® (Brexpiprazole) Tablet is an Atypical Antipsychotic as a “Serotonin-Dopamine Activity Modulator” (SDAM) that combines partial agonist activity at serotonin 5-HT1A and at dopaminergic D2 receptors with antagonist activity at serotonergic 5-HT2A receptors, with similar high affinities at all of these receptors (Ki: 0.1 nM to 0.5 nM).

Brexpiprazole also shows antagonist activity at noradrenergic α1B/2C receptors with affinity in the same sub-nanomolar Ki range (Ki: 0.2 nM to 0.6 nM).

Indication:
Adjunctive treatment for major depressive disorder (MDD) in adult
Treatment of schizophrenia in adult

Dosage and Administration: Schizophrenia:
Starting dose: 1 mg once daily on days 1-4. Recommended dose: 2-4 mg once daily (Be titrated to 2 mg once daily on day 5 through day 7 and then to 4 mg on day 8). Maximum daily dose: 4 mg.

MDD:
Starting dose: 0.5 mg or 1 mg once daily. Recommended dose: 2 mg once daily (Dosage increases should occur at weekly intervals). Maximum daily dose: 3 mg.



Reference: Prescribing Information of REXULTI

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Most Read Articles
Stephen Padilla, 12 Jan 2021
Renin-angiotensin system inhibitors perform better than calcium channel blockers (CCB) at decreasing albuminuria among diabetic and hypertensive patients with nephropathy, according to the results of a systematic review and meta-analysis.
6 days ago
Nearly one-fifth of patients with rheumatoid arthritis (RA) develop ocular complications, as do one-quarter to one-third of those with connective tissue diseases and vasculitis, according to a recent study.
Pearl Toh, Yesterday
Updates from the SECURE-IBD* registry reveal that treatment with thiopurine, either alone or in combination with tumour necrosis factor inhibitors (TNFis), for inflammatory bowel disease (IBD) was associated with a greater risk of severe COVID-19 compared with TNFis monotherapy.
13 Jan 2021
Replacing a refined-grain snack with peanuts in the habitual diet does not significantly change glycaemic or lipid parameters but improves overall metabolic syndrome (MetS) risk without inducing weight gain among adults at high risk of cardiometabolic diseases, according to a China study.