Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
Roshini Claire Anthony, 21 hours ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.

Testosterone therapy improves sexual functioning in men but offers little benefit for ageing symptoms

12 Jan 2020

Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.

The investigators performed English-language searches of several electronic databases (January 1980 to May 2019) and reference lists from systematic reviews. They identified 38 randomized controlled trials (RCTs), with a minimum duration of 6 months, that examined transdermal or intramuscular testosterone therapies vs placebo or no treatment and reported prespecified patient-centred outcomes.

Twenty long-term observational studies, US Food and Drug Administration review data, and product labels reporting harms information were also included in the analysis. The studies mostly involved older men with varying age, symptoms and testosterone eligibility criteria.

In men with low testosterone levels, testosterone therapy correlated with improved sexual functioning and quality of life, but the effect sizes were small, and the evidence had low-to-moderate certainty. Such treatment also demonstrated little to no effect on physical functioning, depressive symptoms, energy and vitality, or cognition.

Harms evidence in RCTs was deemed insufficient or of low certainty for most harm outcomes. In addition, trials were not designed to assess cardiovascular events or prostate cancer and often excluded men at increased risk for these conditions.

On the other hand, confounding by indication and contraindication limited the observational studies.

Few trials exceeded a 1-year duration, minimum important outcome differences were often not established or reported, RCTs were not powered to assess important harms, few data were available in men aged 18–50 years, definitions of low testosterone varied, and study entry criteria varied,” the investigators said.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
Roshini Claire Anthony, 21 hours ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.