Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
2 days ago
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Tenofovir prodrug for CHB on par with tenofovir disoproxil fumarate

07 Jan 2021

HS-10234, a novel tenofovir prodrug, is well-tolerated and as potent as tenofovir disoproxil fumarate (TDF) in the treatment of patients with chronic hepatitis B (CHB) infection, according to the results of a phase Ib trial.

A total of 36 treatment‐naïve adult patients (77.8 percent male; 33.3 percent hepatitis B e antigen [HBeAg]-negative) with noncirrhotic CHB were divided into three groups (n=12 per group). Within each group, patients were randomized to receive 10, 25, or 40 mg of HS‐10234, or 300 mg of TDF once a day for 28 days.

Mean baseline hepatitis B virus (HBV) DNA levels varied between 6.32 and 7.42 log10 IU/mL and did not significantly differ across the treatment groups. The same was true for pretreatment serum hepatitis B surface antigen (HBsAg) and alanine aminotransferase (ALT) levels.

HS-10234 was safe and well-tolerated. A total of 95 adverse events (AEs) occurred in 27 patients (75 percent) and 42 adverse reactions in 24 (66.7 percent). All events were mild or moderate and nonspecific, and none of the patients experienced nephrotoxicity and serious AEs.

In terms of efficacy, serum HBV DNA after 28 days decreased by −2.70, −2.89, −2.72, and −3.04 log10 IU/mL on 10-, 25-, and 40-mg HS‐10234, and 300-mg TDF, respectively.

HS‐10234 and its metabolite tenofovir demonstrated linear, dose‐proportional pharmacokinetics. The concentrations of active metabolite tenofovir diphosphate in peripheral blood mononuclear cells were about two- to 11‐fold higher, while tenofovir concentrations in plasma were approximately 4.5‐ to 25‐fold lower in patients on HS‐10234 than in those on TDF.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
2 days ago
Among patients with moderate-to-severe psoriasis, the use of biologics appears to lower the risk of being hospitalized for the novel coronavirus disease (COVID-19), a new study has found.