Most Read Articles
Jairia Dela Cruz, 22 Apr 2020
A wristwatch-like device that monitors pulse, breathing and blood oxygen levels of the user allows physicians to provide care remotely both in hospital and nontraditional settings, and may help in the fight against the coronavirus disease 2019 (COVID-19) pandemic.
Roshini Claire Anthony, 27 May 2020

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 21 May 2020

Persons suffering from asthma should pay particular attention to SARS-CoV-2 precautionary measures such as social distancing, regular handwashing, and wearing of masks on top of keeping their asthma in control. This is because data collected so far paints a bleaker picture for asthmatics than the normal population should they catch COVID-19.

Natalia Reoutova, Yesterday

A comprehensive review of neurological disorders reported during the current coronavirus disease 2019 (COVID-19) pandemic demonstrates that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects the central nervous system (CNS), the peripheral nervous system (PNS) and muscles, leading the Environmental Neurology Specialty Group of the World Federation of Neurology to propose implementation of international neurological registries.

Tenofovir better than entecavir for minimizing HCC risk in HBV

23 Jan 2020

Tenofovir disoproxil fumarate (TDF) for hepatitis B virus (HBV) infection suppresses hepatocellular carcinoma (HCC) risk better than entecavir, a new study has found.

Researchers retrospectively assessed 29,350 HBV patients (mean age, 52.9±13.2 years; 63.7 percent male) who had received first-line treatment with either TDF (n=1,309; 4.5 percent) or entecavir (n=28,041; 95.5 percent). Participants were followed for 3.6 years for the determination of the cumulative incidence of HCC.

A total of 1,394 patients developed HCC over the observation period, yielding an incidence rate of 4.7 percent. The 1-, 3-, and 5-year cumulative incidence estimates were 1.2 percent, 4.3 percent and 6.8 percent, respectively. Only eight of the HCC cases occurred in the TDF arm (0.6 percent), while the remaining 1,386 (4.9 percent) had been treated with entecavir.

After propensity score matching, patients who were treated with TDF showed a significantly lower risk of developing HCC than their entecavir counterparts (weighted subdistribution hazard ratio [SHR], 0.39, 95 percent confidence interval [CI], 0.18–0.84; p=0.016). This remained true even when analysis was restricted to noncirrhotic patients (weighted SHR, 0.15, 95 percent CI, 0.03–0.74; p=0.02).

The 1-, 3-, and 5-year cumulative incidence rates of HCC in entecavir- vs TDF-treated patients were 0.4 percent vs 0.1 percent, 1.3 percent vs 0.7 percent, and 2.2 percent vs 1.2 percent, respectively.

The present findings warrant further validation in other populations, said researchers. “Future prospective studies would also be valuable to confirm our observations.”

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Most Read Articles
Jairia Dela Cruz, 22 Apr 2020
A wristwatch-like device that monitors pulse, breathing and blood oxygen levels of the user allows physicians to provide care remotely both in hospital and nontraditional settings, and may help in the fight against the coronavirus disease 2019 (COVID-19) pandemic.
Roshini Claire Anthony, 27 May 2020

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 21 May 2020

Persons suffering from asthma should pay particular attention to SARS-CoV-2 precautionary measures such as social distancing, regular handwashing, and wearing of masks on top of keeping their asthma in control. This is because data collected so far paints a bleaker picture for asthmatics than the normal population should they catch COVID-19.

Natalia Reoutova, Yesterday

A comprehensive review of neurological disorders reported during the current coronavirus disease 2019 (COVID-19) pandemic demonstrates that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects the central nervous system (CNS), the peripheral nervous system (PNS) and muscles, leading the Environmental Neurology Specialty Group of the World Federation of Neurology to propose implementation of international neurological registries.