Most Read Articles
Roshini Claire Anthony, Yesterday

Many pregnant women may not be getting adequate nutrition as advised by dietary guidelines, researchers of an Australian study found.

5 days ago
The types of bariatric surgery differentially affect the risk of developing acute pancreatitis postoperatively, such that the risk is greater in patients who undergo vertical sleeve gastrectomy vs Roux-en-Y gastric bypass surgery, according to a study. Risk factors include younger age and presence of gallstones.
Jairia Dela Cruz, 4 days ago
An adjuvant trastuzumab treatment course shortened to 9 weeks has failed to demonstrate noninferiority to the standard 1-year course in terms of disease-free survival in breast cancer patients, although the shortened course confers benefits for the risk of severe cardiac toxicity, according to the results of the phase III randomized Short-HER study.
2 days ago
Atrial fibrillation (AF) appears to accelerate global cognitive decline and increase the risk of dementia in elderly adults, reports a recent study.

Tenofovir alafenamide as good as tenofovir disoproxil fumarate for chronic HBV

27 Jan 2018
Hepatitis B is still widely prevalent worldwide despite effective vaccination programmes in many countries.

In patients with chronic hepatitis B virus (HBV) infection, tenofovir alafenamide (TAF) shows comparable 96-week efficacy and improved renal and bone safety with tenofovir disoproxil fumarate (TDF), a recent study has shown.

Researchers followed-up two international trial cohorts of chronic HBV patients who were randomized 2:1 to receive 25 mg of TAF or 300 mg of TDF. Outcomes included treatment efficacy in each trial and safety in the pooled population.

At 96 weeks post-treatment, both medications resulted in statistically comparable rates of viral suppression in patients positive for the hepatitis B surface antigen, with respective rates of 73 and 75 percent for TAF and TDF (adjusted difference, ‒2.2 percent; 95 percent CI, –8.3 to 3.9 percent; p=0.47).

The same trend was observed in patients negative for the antigen (90 percent vs 91 percent, respectively; adjusted difference, –0.6 percent; –7.0 to 5.8 percent; p=0.84).

In the pooled population for the safety analysis, TAF and TDF were administered to 866 and 432 patients, respectively. Majority of the adverse events reported were mild to moderate in severity, and only a small percentage of participants discontinued due to side effects (2 vs 1 percent, respectively).

Notably, those receiving TAF experienced significantly lower declines in hip bone mineral density (BMD) from baseline to 96 weeks (mean percentage decrease, –0.33 percent; –0.51 to –0.15) relative to those receiving TDF (–2.51 percent; –2.82 to –2.21; p<0.001). The trend was similar for spine BMD.

Finally, median increases in the estimated glomerular filtration rate were likewise significantly lower in TAF than in TDF (–1.2 vs –4.8 mL/min; p<0.001).

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Most Read Articles
Roshini Claire Anthony, Yesterday

Many pregnant women may not be getting adequate nutrition as advised by dietary guidelines, researchers of an Australian study found.

5 days ago
The types of bariatric surgery differentially affect the risk of developing acute pancreatitis postoperatively, such that the risk is greater in patients who undergo vertical sleeve gastrectomy vs Roux-en-Y gastric bypass surgery, according to a study. Risk factors include younger age and presence of gallstones.
Jairia Dela Cruz, 4 days ago
An adjuvant trastuzumab treatment course shortened to 9 weeks has failed to demonstrate noninferiority to the standard 1-year course in terms of disease-free survival in breast cancer patients, although the shortened course confers benefits for the risk of severe cardiac toxicity, according to the results of the phase III randomized Short-HER study.
2 days ago
Atrial fibrillation (AF) appears to accelerate global cognitive decline and increase the risk of dementia in elderly adults, reports a recent study.