Most Read Articles
Pank Jit Sin, 21 Aug 2018

The existence of hepatitis C virus (HCV) infection in an individual is commonly associated with many extra-hepatic manifestations such as skin and auto-immune disorders.

26 Aug 2018
In patients with decompensated cirrhosis, class III obesity increases the risk of acute on chronic liver failure (ACLF) development, a recent study has found.

Tenofovir alafenamide as good as tenofovir disoproxil fumarate for chronic HBV

27 Jan 2018
Hepatitis B is still widely prevalent worldwide despite effective vaccination programmes in many countries.

In patients with chronic hepatitis B virus (HBV) infection, tenofovir alafenamide (TAF) shows comparable 96-week efficacy and improved renal and bone safety with tenofovir disoproxil fumarate (TDF), a recent study has shown.

Researchers followed-up two international trial cohorts of chronic HBV patients who were randomized 2:1 to receive 25 mg of TAF or 300 mg of TDF. Outcomes included treatment efficacy in each trial and safety in the pooled population.

At 96 weeks post-treatment, both medications resulted in statistically comparable rates of viral suppression in patients positive for the hepatitis B surface antigen, with respective rates of 73 and 75 percent for TAF and TDF (adjusted difference, ‒2.2 percent; 95 percent CI, –8.3 to 3.9 percent; p=0.47).

The same trend was observed in patients negative for the antigen (90 percent vs 91 percent, respectively; adjusted difference, –0.6 percent; –7.0 to 5.8 percent; p=0.84).

In the pooled population for the safety analysis, TAF and TDF were administered to 866 and 432 patients, respectively. Majority of the adverse events reported were mild to moderate in severity, and only a small percentage of participants discontinued due to side effects (2 vs 1 percent, respectively).

Notably, those receiving TAF experienced significantly lower declines in hip bone mineral density (BMD) from baseline to 96 weeks (mean percentage decrease, –0.33 percent; –0.51 to –0.15) relative to those receiving TDF (–2.51 percent; –2.82 to –2.21; p<0.001). The trend was similar for spine BMD.

Finally, median increases in the estimated glomerular filtration rate were likewise significantly lower in TAF than in TDF (–1.2 vs –4.8 mL/min; p<0.001).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Hepatology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pank Jit Sin, 21 Aug 2018

The existence of hepatitis C virus (HCV) infection in an individual is commonly associated with many extra-hepatic manifestations such as skin and auto-immune disorders.

26 Aug 2018
In patients with decompensated cirrhosis, class III obesity increases the risk of acute on chronic liver failure (ACLF) development, a recent study has found.