TB chest scars, history predict osteoporosis in Korean males
In Korean male tuberculosis (TB) patients, low bone mineral density and sarcopenia are prevalent, a recent study has shown. Moreover, TB history and TB scars on chest X-rays (CXR) are independent risk factors for osteoporosis.
In the study sample of 3,228 Korean males with available CXR and dual-energy X-ray absorptiometry (DEXA) information, 16.4 percent (n=529) were TB survivors. Only 7.6 percent (n=245) of the total sample had CXR evidence of TB.
Logistic regression analysis, adjusted for age, height, alcohol, smoking and fat mass index (FMI), among others, revealed that the increased odds of sarcopenia were statistically significant only in patients with TB scars on CXR (adjusted odds ratio [OR], 2.05; 95 percent CI, 1.05 to 4.00; p=0.037) and those with both a history of TB and TB scars on CXR (adjusted OR, 3.44; 1.79 to 6.62; p<0.001).
The adjusted ORs for low bone mineral density also showed a significantly increasing trend for those with only a history of TB (OR, 0.79; 0.48 to 1.30), those with only TB scars on CXR (OR, 1.26; 0.89 to 1.78) and those with both features (OR, 2.14; 1.38 to 3.31; p<0.001 for trend).
Similarly, the risk of osteoporosis significantly increased for those with only a history of TB (OR, 1.13; 0.44 to 2.90), only TB scars on CXR (OR, 1.37; 0.86 to 2.18) and those with both features (OR, 1.75; 1.04 to 2.95; p=0.028 for trend).