Most Read Articles
6 days ago
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

3 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
Pearl Toh, 3 days ago
Drinking more water did not significantly slow down the decline in kidney function of patients with stage 3 chronic kidney disease (CKD) at 1 year compared with patients who maintained their daily water intake, the CKD WIT* randomized study suggests.

TAVR safer than SAVR in terms of bleeding, acute kidney injury, atrial fibrillation

26 Apr 2018
In intermediate risk patients, the TAVR is found to have better outcomes

Transcatheter aortic valve replacement (TAVR) in severe symptomatic aortic stenosis (AS) patients is superior to conventional surgical aortic valve replacement (SAVR) in terms of reducing life-threatening bleeding, new-onset atrial fibrillation and acute kidney injury, a recent meta-analysis has found.

Pooled analysis of four studies (n=4,355; TAVR: n=2,222) showed that, at 2-year follow-up, TAVR was associated with a significantly lower rate of life-threatening bleeding (risk ratio [RR], 0.45; 95 percent CI, 0.28–0.73; p=0.001), acute kidney injury (RR, 0.48; 0.25–0.93; p=0.03) and new atrial fibrillation (RR, 0.46; 0.33–0.64; p<0.0001).

In contrast, TAVR was inferior to SAVR in terms of permanent pacemaker implantation (RR, 3.01; 1.04–8.72; p=0.04) and aortic-valve reintervention (RR, 3.22; 1.64–6.29; p=0.0006), both of which were significantly more frequent in TAVR patients.

There were no significant differences between the two treatments in terms of deaths (TAVR: 13.7 percent vs SAVR: 15.1 percent; RR, 0.86; 0.67–1.10; p=0.22) and cardiovascular mortality rates (8.87 percent vs 10.08 percent; RR, 0.88; 0.73–1.06; p=0.17). The incidences of stroke (RR, 0.90; 0.73–1.10; p=0.31) and myocardial infarction (RR, 0.99; 0.70–1.39; p=0.93) were also comparable between the interventions.

For the meta-analysis, the databases of PubMed, CENTRAL and EBSCO were searched for randomized controlled trials of patients with severe aortic valve stenosis at low-to-intermediate surgical risk. For inclusion, trials should have compared the safety and clinical outcomes between TAVR and SAVR.

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Most Read Articles
6 days ago
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

3 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
Pearl Toh, 3 days ago
Drinking more water did not significantly slow down the decline in kidney function of patients with stage 3 chronic kidney disease (CKD) at 1 year compared with patients who maintained their daily water intake, the CKD WIT* randomized study suggests.