Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

TAVR improves long-term survival in the very old

20 Dec 2019

Nonagenarians with severe aortic stenosis (AS) enjoy long-term survival benefits after transcatheter aortic valve replacement (TAVR), a recent study has found.

Researchers enrolled 1,052 consecutive patients with severe AS scheduled for TAVR, who were divided into three groups according to their age at the time of the procedure: 80–84 years (group 1; n=658), 85–89 years (group 2; n=326) and 90 years (group 3; n=68). Patient survival after TAVR were compared among groups and against an age- and sex-matched general-population control.

Patients in group 3 were significantly more likely to develop major access-site complications than their younger comparators (7.6 percent vs 10.1 percent vs 17.6 percent; p=0.016). Nonagenarians also had greater need for blood transfusion (24.1 percent vs 32.5 percent vs 38.2 percent; p=0.003).

The composite endpointlife-threatening bleeding, stroke, stage 2/3 acute kidney injury, major vascular complications, coronary obstruction requiring intervention, repeat procedures for valve-related dysfunction and all-cause mortalityoccurred more frequently in the oldest patient group (13.5 percent vs 17.5 percent vs 27.9 percent; p=0.004).

Compared to a general-population cohort, nonagenarians showed greater 1-year mortality after being treated with TAVR (27.8 percent vs 20.0 percent). Mortality curves converged by year 2 (39.2 percent vs 37.5 percent) and reversed positions after 5 years, such that survival was better in those who received TAVR (mortality rates: 59.2 percent vs 74.2 percent).

This underscores the importance of TAVR and its efficacy for improving survival, even in an elderly population of patients, researchers said.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.