Most Read Articles
4 days ago
A recent study has shown no improvement in the rate of blood pressure (BP) control despite an increase in the prevalence of antihypertensive medication use.
29 Jan 2020
Several high-density lipoprotein (HDL) functionality parameters, which are linked to HDL roles on cholesterol metabolism, endothelial protection and antioxidant/anti-inflammatory defence, contribute to an increased risk of incident acute coronary syndromes and its manifestations in individuals at high risk of cardiovascular disease, a study reports.
Jairia Dela Cruz, 25 Nov 2019
Use of the PCSK9* inhibitor alirocumab in acute coronary syndrome (ACS) patients on a background of high-intensity statin treatment delivers reductions in total hospitalizations and death with corresponding gains in days alive and out of hospital (DAOH), according to the results of prespecified and posthoc analyses of the ODYSSEY OUTCOMES** trial presented at the American Heart Association (AHA) 2019 Scientific Sessions.
09 Feb 2020
Short-term, reading-to-reading ambulatory blood pressure (BP) variability appears to be associated with total and cardiovascular mortality among individuals with hypertension, according to data from the Spanish ABPM Registry.

TAVR effective in both bicuspid and tricuspid valves

17 Jan 2020

Bicuspid (BAV) and tricuspid (TAV) aortic valve patients have comparable 30-day and 1-year mortality outcomes after transcatheter aortic valve replacement (TAVR), reports a recent meta-analysis. Rates of stroke and new pacemaker implants are likewise similar.

Accessing the databases of Medline, Central, The Cochrane Controlled Trials Register, ProQuest and Google Scholar, researchers retrieved 13 observational studies, corresponding to 11,034 patients, for the comparison between TAV and BAV. Another seven studies (n=706) were included for the comparison of balloon-expandable and self-expandable bioprostheses.

The primary outcome of 30-day mortality occurred similarly between patients with BAV vs TAV after TAVR (odds ratio [OR], 1.13, 95 percent confidence interval [CI], 0.88–1.46; p=0.33). The same was true for 1-year mortality (OR, 1.02, 0.77–1.37; p=0.87).

Similarly, stroke (OR, 1.22, 95 percent CI, 0.89–1.66; p=0.21), vascular complications (OR, 1.09, 95 percent CI, 0.79–1.51; p=0.59), acute coronary artery obstruction (OR, 1.56, 95 percent CI, 0.80–3.04; p=0.20), acute kidney injury (OR, 1.32, 95 percent CI, 0.74–2.35; p=0.34) and the need for a new pacemaker implant (OR, 1.09, 95 percent CI, 0.88–1.34; p=0.44) were comparable between BAV and TAV patients.

On the other hand, BAV patients were significantly more likely than their TAV counterparts to convert to conventional surgery (OR, 2.35, 95 percent CI, 1.30–4.23; p=0.005). They were also more likely to need the implantation of a second valve (OR, 2.06, 95 percent CI, 1.31–3.25; p=0.002) and were at greater risk of moderate/severe paravulvar leakage (OR, 1.67, 95 percent CI, 1.29–2.17; p=0.0001) and device failure (OR, 1.26, 95 percent CI, 1.02–1.56; p=0.04).

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Most Read Articles
4 days ago
A recent study has shown no improvement in the rate of blood pressure (BP) control despite an increase in the prevalence of antihypertensive medication use.
29 Jan 2020
Several high-density lipoprotein (HDL) functionality parameters, which are linked to HDL roles on cholesterol metabolism, endothelial protection and antioxidant/anti-inflammatory defence, contribute to an increased risk of incident acute coronary syndromes and its manifestations in individuals at high risk of cardiovascular disease, a study reports.
Jairia Dela Cruz, 25 Nov 2019
Use of the PCSK9* inhibitor alirocumab in acute coronary syndrome (ACS) patients on a background of high-intensity statin treatment delivers reductions in total hospitalizations and death with corresponding gains in days alive and out of hospital (DAOH), according to the results of prespecified and posthoc analyses of the ODYSSEY OUTCOMES** trial presented at the American Heart Association (AHA) 2019 Scientific Sessions.
09 Feb 2020
Short-term, reading-to-reading ambulatory blood pressure (BP) variability appears to be associated with total and cardiovascular mortality among individuals with hypertension, according to data from the Spanish ABPM Registry.