Most Read Articles
Pearl Toh, 3 days ago
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.

Targeting nanotherapy a promising treatment for abdominal aortic aneurysms

02 Dec 2018

The multifunctional, targeting nanotherapy shows potential in the treatment of abdominal aortic aneurysms (AAA), a recent study suggests.

“The underlying design principles enable the development of a broad range of nanomedicines for targeted therapy of other vascular disease,” the authors said.

A rapamycin-loaded responsive nanotherapy was formulated successfully based on a facile and translational method. This medicine could release drug molecules upon the trigger by high levels of reactive oxygen species (ROS).

Calcification was significantly prevented while ROS-mediated oxidative stress and apoptosis were attenuated by the nanotherapy in cells linked to the development of AAAs.

Passively targeting aneurysms and releasing drug molecules in response to the inflammatory microenvironment allowed the intravenously injected ROS-responsive nanotherapy to more effectively prevent aneurysm expansion in AAA rats than a nonresponsive control nanotherapy.

There was further improvement in the aneurysmal targeting capability and therapeutic effects of a ROS-responsive nanotherapy with a mean diameter of 190 nm after decoration with a peptide ligand cRGDfK and macrophage cell membrane. The nanotherapy was also safe according to a preliminary safety test.

This study sought to develop a nanotherapy that can target aneurysms and release drug molecules in response to the inflammatory microenvironment. The nanotherapy was developed using a ROS-responsive nanoparticle and a candidate drug rapamycin, in combination with a peptide ligand for integrin and biomimetic cloaking with macrophage cell membrane. Its efficacy was shown by in vitro and in vivo studies.

“AAA is a leading cause of mortality and morbidity in the elderly,” the authors said. “Currently, there remain no effective drugs that can prevent the growth of aneurysms and delay aneurysm rupture in the clinical setting.”

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Most Read Articles
Pearl Toh, 3 days ago
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.