Most Read Articles
11 Nov 2019
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
11 Nov 2019
Multiple intralesional injections with purified protein derivative (PPD) leads to faster clearance of common warts compared with a single injection, although the latter is better tolerated, as shown in the results of an open‐label, superiority trial.
17 Oct 2019
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.
Rachel Soon, 5 days ago

The third Pharmaceutical Industry Pharmacists Insight (PIPI 3.0) symposium will highlight areas of the pharmaceutical industry often overlooked by those entering the pharmacy profession.

Tapinarof proven safe, effective for psoriasis in phase II trial

11 Mar 2019
From the survey conducted, it is found that more than 80% of patients with psoriasis have experienced discrimination or humiliation across the world.

A phase II study has shown the efficacy and safety of tapinarof cream in adult patients with psoriasis.

The investigators assessed the safety and efficacy of tapinarof in a new cream formulation at two concentrations and with two application frequencies in this double-blind, vehicle-controlled, randomized, six-arm trial. Participants included adults with psoriasis with body surface involvement ≥1 percent and ≤15 percent and Physician Global Assessment (PGA) score ≥2 at baseline.

PGA of 0 or 1 at week 12 and a 2-grade improvement from baseline were the primary endpoints. Further analyses included assessment of ≥75-percent improvement of Psoriasis Area and Severity Index (PASI) and mean percent change in PASI and body surface area involvement.

Patients in the tapinarof groups had statistically significantly higher (at a 0.05 significance level) treatment success, defined by PGA 0 or 1 and a 2-grade improvement at week 12 (65 percent [1% twice daily], 56 percent [1% once daily], 46 percent [0.5% twice daily] and 36 percent [0.5% once daily]) than those in the vehicle groups (11 percent [twice daily] and 5 percent [once daily]).

Treatment success was maintained for 4 weeks post-treatment.

However, patients treated with tapinarof (85/152; 56 percent) were more likely to experience treatment-emergent adverse events (TEAEs) than those in the vehicle group (19/75; 25 percent). TEAEs were mild-to-moderate in intensity. Moreover, severe TEAEs were reported in all tapinarof groups except the 0.5% once-daily group.

Large confirmation trials are warranted, according to the investigators.

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Most Read Articles
11 Nov 2019
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
11 Nov 2019
Multiple intralesional injections with purified protein derivative (PPD) leads to faster clearance of common warts compared with a single injection, although the latter is better tolerated, as shown in the results of an open‐label, superiority trial.
17 Oct 2019
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.
Rachel Soon, 5 days ago

The third Pharmaceutical Industry Pharmacists Insight (PIPI 3.0) symposium will highlight areas of the pharmaceutical industry often overlooked by those entering the pharmacy profession.