Most Read Articles
6 days ago
Survival in age-related macular degeneration (AMD) may be lower in patients with late disease, bilateral cataract surgery and poor visual acuity, according to data from the Age-Related Eye Disease Study 2. Moreover, oral supplementation with omega-3 fatty acids, lutein plus zeaxanthin, zinc or beta-carotene does not significantly affect mortality.
04 Dec 2017
Later timing of puberty seems to correlate with lower areal bone mineral density in children and may affect the eventual risk of osteoporosis, a recent study suggests.
Jairia Dela Cruz, 6 days ago
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
3 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.

Talimogene laherparepvec-ipilimumab combo useful in treatment of advanced melanoma

4 days ago

The combination of talimogene laherparepvec plus ipilimumab demonstrates greater antitumour activity in patients with advanced, unresectable melanoma compared with ipilimumab alone, without having additional safety concerns, according to the results on an open-label phase II study.

A total of 198 patients with stages IIIB to IV disease were randomized to receive talimogene laherparepvec plus ipilimumab (n=98) or ipilimumab alone (n=100). Treatment with talimogene laherparepvec was initiated at week 1 (first dose, ≤4 mL × 106 plaque-forming units/mL; after 3 weeks, ≤4 mL × 108 plaque-forming units/mL every 2 weeks). On the other hand, ipilimumab (3 mg/kg every 3 weeks; up to four doses) was started at week 1 in the monotherapy arm and week 6 in the combination arm.

Over a median of 68 weeks of follow-up, the primary endpoint of objective response rate, evaluated by investigators per immune-related response criteria, was 39 percent in the combination arm vs 18 percent in the monotherapy arm (odds ratio, 2.9; 95 percent CI, 1.5 to 5.5; p=0.002).

Responses were observed beyond injected lesions. In particular, visceral lesion reductions were seen in 52 percent of patients in the combination arm vs 23 percent in the monotherapy arm.

Commonly reported adverse events (AEs) included fatigue (combination, 59 percent; monotherapy, 42 percent), chills (combination, 53 percent; monotherapy, 3 percent) and diarrhoea (combination, 42 percent; monotherapy, 35 percent). Grade ≥3 AEs occurred in 45 percent of patients treated with the talimogene laherparepvec-ipilimumab combination and in 35 percent of those who received ipilimumab alone. Fatal AEs occurred in three patients in the combination arm, although none were treatment related.

The present data suggest that the combination of talimogene laherparepvec and a checkpoint inhibitor may have significant clinical utility in treatment of advanced melanoma, researchers said.

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Most Read Articles
6 days ago
Survival in age-related macular degeneration (AMD) may be lower in patients with late disease, bilateral cataract surgery and poor visual acuity, according to data from the Age-Related Eye Disease Study 2. Moreover, oral supplementation with omega-3 fatty acids, lutein plus zeaxanthin, zinc or beta-carotene does not significantly affect mortality.
04 Dec 2017
Later timing of puberty seems to correlate with lower areal bone mineral density in children and may affect the eventual risk of osteoporosis, a recent study suggests.
Jairia Dela Cruz, 6 days ago
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
3 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.