Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, 23 hours ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.

Tadalafil does not help lessen ambulatory ability decline in boys with DMD

12 Dec 2017

Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.

The study randomized 331 boys (mean age 9.6 years) with DMD to receive tadalafil 0.3 mg·kg−1·d−1, tadalafil 0.6 mg·kg−1·d−1 or placebo for 48 weeks. Efficacy was assessed using the 6-minute walk distance (6MWD). Secondary efficacy measures were North Star Ambulatory Assessment and timed function tests. Performance of Upper Limb (PUL) was examined as a prespecified exploratory outcome.

Tadalafil did not exert an effect on the primary outcome. The 6MWD after 48 weeks of treatment decreased by 51.0 m with placebo, 64.7 m with low-dose tadalafil (p=0.307 vs placebo) and 59.1 m with high-dose tadalafil (p=0.538 vs placebo). The drug had no effect on secondary outcomes.

In the group of patients aged >10 years, those treated with low-dose tadalafil showed smaller declines in total PUL score and shoulder subscore compared with those who received placebo.  

Drug-related adverse events were reported in 41.4 percent of patients in the placebo group, 50.0 percent in the low-dose tadalafil group and 59.8 percent in the high-dose tadalafil group.

Adverse events were consistent with the known safety profile of tadalafil and the DMD disease state, researchers noted. “Safety monitoring revealed the expected increase in penile erections with tadalafil without priapism.”

Additional research is warranted to determine whether ambulatory decline in DMD can be lessened by initiation of PDE5 inhibition before 7 years of age, researchers said.

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Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, 23 hours ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.