Most Read Articles
Tristan Manalac, 26 Sep 2017
Depression seems to be a significant independent predictor of recurrent chest pain (RCP) in patients with acute chest pain, regardless of cardiac ischaemia, a recent study has shown.
Stephen Padilla, 08 Aug 2017
Mechanical cardiopulmonary resuscitation (CPR) devices offer a survival benefit as compared to manual CPR only when applied early on-site in the management of out-of-hospital cardiac arrest (OHCA), according to a Singapore study.
Pank Jit Sin, 22 Sep 2015
When it comes to information and health advice about erectile dysfunction (ED), Malaysian men may be barking up the wrong tree, reveals a survey. 
21 Dec 2017
Physicians’ practice patterns in managing hypertension, and their awareness of blood pressure variability, were reported in a recent study in Singapore. We discussed some of the clinical practice gaps identified by this study with author, A/Prof. Teo Boon Wee.

T786C polymorphism in endothelial nitric oxide synthase gene tied to in-stent restenosis after drug-eluting stent

02 Feb 2017

The T786C polymorphism in the endothelial nitric oxide synthase gene is associated with in-stent restenosis in a Chinese Han population treated with drug-eluting stent, a new study reports.

Researchers recruited 425 patients diagnosed with coronary artery disease. For inclusion, participants had to have successfully undergone revascularization in the native coronary arteries through drug-eluting stent.

To identify the six putative single-nucleotide polymorphisms, genotyping was performed on the endothelial nitric oxide synthase gene, the angiotensin II type 1 receptor gene, the angiotensin converting enzyme gene, the vascular endothelial growth factor gene and the transforming growth factor beta gene.

During the follow-up period, quantitative coronary angiography was performed on the patients to detect in-stent restenosis. Pertinent and relevant associations were evaluated using logistic regression models.

Of all the participants, 54 (12.7 percent) were found to develop in-stent restenosis during the course of the study. Interestingly, this group showed significantly increased frequency of the C allele of the T786C polymorphism in the endothelial nitric oxide synthase gene compared with the group without in-stent restenosis (p<0.01).

The frequencies of other genotypes were not significantly different from each other.

After adjusting for confounders, the multivariable analysis showed that an increased risk of in-stent restenosis was associated with both the additive (odds ratio [OR], 1.870; 95 percent CI, 1.079 to 3.240; p=0.03) and dominant (OR, 2.045; 1.056 to 3.958; p=0.03) models of the T786C polymorphism.

The findings show that in-stent restenosis is associated with the T786C polymorphism in the endothelial nitric oxide synthase gene in patients who have received drug-eluting stent.

The authors recommend employing genotyping programmes to better identify those at high risk of in-stent restenosis following drug-eluting stent implantation.

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Most Read Articles
Tristan Manalac, 26 Sep 2017
Depression seems to be a significant independent predictor of recurrent chest pain (RCP) in patients with acute chest pain, regardless of cardiac ischaemia, a recent study has shown.
Stephen Padilla, 08 Aug 2017
Mechanical cardiopulmonary resuscitation (CPR) devices offer a survival benefit as compared to manual CPR only when applied early on-site in the management of out-of-hospital cardiac arrest (OHCA), according to a Singapore study.
Pank Jit Sin, 22 Sep 2015
When it comes to information and health advice about erectile dysfunction (ED), Malaysian men may be barking up the wrong tree, reveals a survey. 
21 Dec 2017
Physicians’ practice patterns in managing hypertension, and their awareness of blood pressure variability, were reported in a recent study in Singapore. We discussed some of the clinical practice gaps identified by this study with author, A/Prof. Teo Boon Wee.