Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
3 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.

Systematic biopsy urged in patients with negative MRI

10 Oct 2020

Magnetic resonance imaging (MRI) is vital for the detection of high-grade cancer, and a recent study further adds to this data by recommending systematic biopsy in patients with negative MRI and the inclusion of systematic biopsy in those with positive MRI.

Men enrolled in Canary Prostate Active Surveillance Study with Gleason grade group <2 and who underwent biopsy within 12 months of multiparametric MRI were included in this analysis. Biopsy reclassification to Gleason grade group 2 was the primary outcome.

The authors assessed the performance of MRI Prostate Imaging–Reporting and Data System (PI-RADS) score and clinical factors. They also fitted multivariable logistic regression models with MRI and clinical factors and used these models to perform receiver operating curve analyses.

Overall, 361 participants with 395 prostate MRI studies, with a median follow-up of 4.1 years (interquartile range, 2.0-7.6), were included. One hundred eight (27 percent) biopsies demonstrated reclassification.

Defining positive MRI as PI-RADS 3-5, the negative and positive predictive values for detecting Gleason grade group 2 cancer was 83 percent (95 percent confidence interval [CI], 76–90) and 31 percent (95 percent CI, 26–37), respectively.

In a multivariable model, PI-RADS significantly correlated with reclassification (PI-RADS 5 vs 1 and 2; odds ratio, 2.71, 95 percent CI, 1.21–6.17; p=0.016), but it did not improve upon a model with only clinical factors (AUC, 0.768 vs 0.762).

In 194 fusion biopsies, higher grade cancer was detected in targeted cores in 21 instances (11 percent). On the other hand, 24 (13 percent) had higher grade cancer in the systematic cores.

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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
3 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.