Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
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At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 13 Jan 2020
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Syndromes affecting bowel health in cancer survivors may occur as late effects of pelvic radiotherapy

09 Feb 2017

Five symptoms that affect bowel health may be attributed to late effects of radiotherapy, new study reports. Studying the underlying causes of these symptoms should simplify the prevention and treatment of a variety of other downstream symptoms.

A total of 623 survivors who had received external pelvic radiotherapy for gynaecological malignancies between 1991 and 2003 were recruited for the study. Simultaneously, 344 eligible and matched women were included as controls.

Survivors were then followed up for at least 2 and at most 15 years after radiotherapy. Both patients and controls completed questionnaires designed to extract information and symptoms regarding bowel health.

As per the parallel analysis, six factors were found to optimally explain the correlation structure among the symptoms. Of these, only five were statistically different between controls and patients.

The five factors were urgency syndrome, excessive gas discharge, blood discharge, leakage syndrome and excessive mucus discharge. The sixth factor, constipation, was comparable between controls and patients.

When designated as radiation-induced syndromes reflecting survivorship diseases, the five factors cumulatively accounted for 42 percent of the variance of all the symptoms examined in the study.

Of the gynaecological cancer survivors, 30 percent had urgency syndrome, 26 percent had leakage syndrome, 15 percent had excessive gas discharge, 16 percent had excessive mucus discharge, and 10 percent had blood discharge.

The findings show that the five factors may impact on bowel health in gynaecological cancer survivors who have undergone radiotherapy. Further studies on these factors, instead of on the 28 bowel symptoms, may prove more efficient at identifying a viable prevention and treatment technique.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 13 Jan 2020
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.
Stephen Padilla, 6 days ago
The Lancet Commission on Hypertension Group has recently released a position statement that contains a list of recommendations for the improvement of accuracy standards for devices that measure blood pressure (BP).