Most Read Articles
Stephen Padilla, 2 days ago
The use of povidone iodine (PI) is more effective than chlorhexidine gluconate (CHG) at reducing vaginal bacterial colony counts in pregnancy and appears to be a superior vaginal antiseptic for decreasing postpartum infections, according to a study presented at the 2020 Annual Meeting of the Society for Maternal-Fetal Medicine (SMFM 2020).
Jairia Dela Cruz, 5 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
5 days ago
Higher concentrations of distinct ceramide species, known to be linked to adverse metabolic health, are associated with cumulative sugar-sweetened beverage (SSB) consumption that contributes to the development of cardiometabolic diseases, suggests a study.
6 days ago
Impaired fasting glucose appears to be a stronger risk factor for type 2 diabetes mellitus (T2DM) than metabolic syndrome (MetS), reports a new Japan study. The coexistence of the two factors confers the highest T2DM risk.

Switching to benralizumab improves OCS dosing, QoL in patients with severe eosinophilic asthma

Elaine Soliven
11 Jun 2019
Dr Joanne Kavanagh

Switching from mepolizumab to benralizumab led to a significant reduction in oral corticosteroid (OCS) dose and a better QoL* in patients with severe eosinophilic asthma (SEA), according to a small study presented at ATS 2019.

“Mepolizumab and benralizumab have proven steroid-sparing efficacy in SEA … Mechanistically, it is possible that the greater eosinophil-depleting properties of benralizumab may confer superior clinical efficacy over mepolizumab in these patients,” said Dr Joanne Kavanagh from the Department of Respiratory Medicine at Guy’s Hospital, Guy’s and St Thomas’ NHS Foundation Trust in London, UK.

The researchers retrospectively analysed 15 OCS-dependent patients with SEA (mean age 47.67 years, 60 percent female, mean BMI 32.86 kg/m2) who were treated with subcutaneous mepolizumab 100 mg for ≥6 months, and then switched to subcutaneous benralizumab 30 mg for another 16 weeks, with an ongoing OCS requirement of prednisolone ≥7.5 mg or equivalent. [ATS 2019, abstract A2675/P510]

The daily OCS dose was reduced by 25 percent among OCS-dependent patients treated with benralizumab compared with mepolizumab at the last visit (median OCS dose, 7.5 vs 10 mg/day; p=0.046).

Patients who received benralizumab also had a significantly higher score on the Asthma Quality of Life Questionnaire, indicating no impairment, than those treated with mepolizumab (4.08 vs 3.56; p=0.041).

An improved Asthma Control Questionnaire-6 score, as shown by a lower score, was also observed in patients who received benralizumab compared with mepolizumab (2.89 vs 3.13; p=0.68), although this was not significant.

Changes in FeNO** and post-bronchodilator FEV1*** ratios, as well as exacerbation rates were not significantly different between the benralizumab and mepolizumab treatment groups.

“[Even] in a small cohort of such patients, we have observed that switching some of these subjects to benralizumab appears to result in a significant reduction in their maintenance OCS dose and an improvement in their quality of life scores,” Kavanagh said.

“[However,] we also observed that some patients with an eosinophilic phenotype fail[ed] to adequately respond to either mepolizumab or benralizumab … Controlled studies in larger numbers are required to explore this possibility further,” she noted.

 

*QoL: Quality of life

**FeNO: Fractional concentration of exhaled nitric oxide

***FEV1: Forced expiratory volume in 1 second
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Singapore digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 2 days ago
The use of povidone iodine (PI) is more effective than chlorhexidine gluconate (CHG) at reducing vaginal bacterial colony counts in pregnancy and appears to be a superior vaginal antiseptic for decreasing postpartum infections, according to a study presented at the 2020 Annual Meeting of the Society for Maternal-Fetal Medicine (SMFM 2020).
Jairia Dela Cruz, 5 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
5 days ago
Higher concentrations of distinct ceramide species, known to be linked to adverse metabolic health, are associated with cumulative sugar-sweetened beverage (SSB) consumption that contributes to the development of cardiometabolic diseases, suggests a study.
6 days ago
Impaired fasting glucose appears to be a stronger risk factor for type 2 diabetes mellitus (T2DM) than metabolic syndrome (MetS), reports a new Japan study. The coexistence of the two factors confers the highest T2DM risk.