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Sweltering weather may be a blessing in osteoporosis

17 Dec 2020

Exposure to warm weather has the potential to prevent bone loss and fractures, with a recent study showing that it can improve bone strength in adulthood and prevent osteoporosis in mice.

A team of researchers investigated whether heat applied postdevelopmentally in healthy and during osteoporotic states would exert positive effects on bone strength. They conducted a human metadata analysis on the incidence of hip fractures per capita and country worldwide.

Results revealed an inverse association between average temperature and hip fracture incidence. This was independent of vitamin D and calcium levels.

To further investigate, the team housed a group of mice at 34 °C and another group at room temperature for 8 weeks. Interestingly, exposure to warm temperature prevented ovariectomy-induced bone loss in adult female and young male mice. This benefit was attributed to increased trabecular bone volume, connectivity density, and thickness, leading to improved biomechanical bone strength—an effect that was not related to food intake.

Additionally, in ovariectomized mice (an osteoporosis model), exposure to warm temperature after surgery prevented the bone loss observed in controls housed at room temperature.

Combinatorial metagenomics/metabolomics analysis showed that warmth could boost bacterial polyamine biosynthesis, leading to higher total polyamine levels in vivo. Spermine and spermidine supplementation appeared to enhance bone strength, whereas inhibiting polyamine biosynthesis in vivo curbed the beneficial effects of warm temperature on the bone.

Additional investigation should inform the possibility of using warm temperature exposure as a treatment option for osteoporosis.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.