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Survival in HPV-associated cancers vary by age, race

14 Nov 2017

The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.

Survival data from 27 population-based US cancer registries were retrieved and used in the analysis. Only cases of invasive cancers that fulfilled the criteria for HPV association were included. The overall and relative 5-year survival rates were calculated for patients diagnosed from 2001 to 2011.

In the study sample of 220,211 patients with HPV-associated cancers, the most common cancer types were oropharyngeal squamous cell carcinomas (SCCs) and cervical carcinomas, observed in 36.4 and 36.1 percent, respectively.

These were followed by anal SCCs (11.8 percent), vulvar SCCs (8.8 percent), penile SCCs (2.8 percent), vaginal SCCs (2.2 percent) and rectal SCCs (1.9 percent).

Five-year age-standardized survival rates were highest for vulvar (66 percent) and anal (65.9 percent) SCCs. In contrast, penile (47.4 percent) and oropharyngeal (51.2 percent) SCCs had the lowest survival rates out of all included cancer types.

Survival for cervical carcinomas, penile SCCs and oropharyngeal SCCs consistently declined with increasing age. On the other hand, those diagnosed with vaginal, vulvar and anal SCCs between the ages of 40 and 49 years had slightly higher survival than those diagnosed at <40 years.

Five-year age-standardized relative survival was higher in Caucasians than African-Americans for cervical carcinomas (64.8 vs 57 percent), penile SCCs (48.4 vs 34.7 percent), anal SCCs (69.3 vs 59.8 percent), rectal SCCs (61.2 vs 45.5 percent) and oropharyngeal SCCs (53.5 vs 32.4 percent).

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Most Read Articles
3 days ago
Prenatal and postpartum vitamin D supplementation does not appear to improve foetal or infant growth, a study reports.
5 days ago
Excessive daytime sleepiness appears to increase the long-term risk of amyloid β (Aβ) deposition, a recent study has shown.
5 days ago
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
6 days ago
Among obese and overweight adults with type 2 diabetes mellitus, women appear to be less likely than men to develop mild cognitive impairment, independent of traditional risk factors, a recent study has shown.