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01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

Surgical castration use remains low despite advantage in metastatic prostate cancer

25 Apr 2020

Surgical castration for metastatic prostate cancer has potential advantages and similar survival rate compared to medical castration, but its use is still low and even decreasing in a contemporary, real-world cohort, reveals a study.

“Surgical castration for metastatic prostate cancer is used less frequently than medical castration yet costs less, requires less follow-up and may be associated with fewer adverse effects,” the authors said.

Overall, 24,805 men with newly diagnosed metastatic prostate cancer from a national cancer registry in the US (2004 to 2016) were enrolled in this retrospective cohort study. The association between surgery and sociodemographic factors was assessed using multivariable logistic regression, while the association between castration type and overall survival was examined via multivariable Cox regression.

Of the patients, 5.4 percent underwent surgical castration, which showed a significant decrease from 8.5 percent in 2004 to 3.5 percent in 2016 (per year later odds ratio [OR], 0.89, 95 percent confidence interval [CI], 0.87–0.91; p<0.001).

Private insurance (OR, 0.73, 95 percent CI, 0.61–0.87; p<0.001) was associated with fewer surgery, while Medicaid (OR, 1.68, 95 percent CI, 1.34–2.11; p<0.001) or no insurance (OR, 2.12, 95 percent CI, 1.58–2.85; p<0.001) correlated with more compared to Medicare.

Moreover, surgery was also fewer among men with regional median income >$63,000 compared with income <$38,000 (OR, 0.61, 95 percent CI, 0.43–0.85; p=0.004).

After a median follow-up of 30 months, castration type did not show an association with differences in survival (surgical vs medical hazard ratio, 1.02, 95 percent CI, 0.95–1.09; p=0.6).

“Men with potentially limited healthcare access undergo more surgery, perhaps reflecting a provider bias toward the perceived benefit of permanent castration,” the authors said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.