Most Read Articles
2 days ago
Exposure to corticosteroids in patients with autoimmune hepatitis (AIH) appears to contribute to increased risks of cataract, diabetes and bone fractures, a study has found. Notably, the fracture risk is elevated at low doses, while the risk of adverse events overall is dose-dependent and is reversible.
6 days ago
In patients with atrial fibrillation (AF) and stable coronary artery disease (CAD), rivaroxaban monotherapy is noninferior to combination treatment with an antiplatelet therapy in terms of cutting the risk of cardiovascular events and mortality, according to data from the AFIRE trial.
Elvira Manzano, 12 Nov 2019
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
Jairia Dela Cruz, 5 days ago
Many patients with nonvalvular atrial fibrillation (NVAF) in Thailand use anticoagulants, but the uptake of nonvitamin-K oral anticoagulants remains suboptimal despite showing an upward trend, according to data from the COOL-AF registry presented at the European Society of Cardioloy (ESC) Asia Congress 2019 with APSC and AFC.

Surgical aortic valve replacement may shorten life expectancy

09 Jul 2019
In intermediate risk patients, the TAVR is found to have better outcomes

Patients who had undergone aortic valve replacement (AVR) have shorter life expectancy than the general population, a study has found. Apart from being substantial, this loss in life expectancy increases with younger age.

During a mean follow-up of 6.8 years, the loss in life expectancy stood at 1.9 years (95 percent CI, 1.2–2.6 years) in patients who underwent primary surgical AVR. The 19-year observed survival rate was 21 percent, while the expected and relative survival rates were 34 percent and 63 percent (59–67 percent), respectively.

Younger age increased the estimated loss in life expectancy: 0.4 (0.3–0.5 years) vs 4.4 years (1.5–7.2 years) in patients ≥80 and <50 years of age, respectively. No difference was seen in loss in life expectancy between men and women.

“These results provide important information to quantify disease burden after AVR and are relevant for clinicians counseling patients before and after AVR,” the investigators said.

In total, 23,528 patients who underwent AVR with or without concomitant coronary artery bypass grafting in Sweden between 1995 and 2013 from the SWEDEHEART (Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies) register were included in the study.

Individual-level linking with other national health-data registers was conducted to gather baseline characteristics and vital status. The Human Mortality Database was accessed to obtain the expected survival from the general Swedish population matched by age, sex and year of surgery. The investigators used the relative survival as an estimate of cause-specific mortality and flexible parametric models based on relative survival to estimate the loss in life expectancy.

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Most Read Articles
2 days ago
Exposure to corticosteroids in patients with autoimmune hepatitis (AIH) appears to contribute to increased risks of cataract, diabetes and bone fractures, a study has found. Notably, the fracture risk is elevated at low doses, while the risk of adverse events overall is dose-dependent and is reversible.
6 days ago
In patients with atrial fibrillation (AF) and stable coronary artery disease (CAD), rivaroxaban monotherapy is noninferior to combination treatment with an antiplatelet therapy in terms of cutting the risk of cardiovascular events and mortality, according to data from the AFIRE trial.
Elvira Manzano, 12 Nov 2019
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
Jairia Dela Cruz, 5 days ago
Many patients with nonvalvular atrial fibrillation (NVAF) in Thailand use anticoagulants, but the uptake of nonvitamin-K oral anticoagulants remains suboptimal despite showing an upward trend, according to data from the COOL-AF registry presented at the European Society of Cardioloy (ESC) Asia Congress 2019 with APSC and AFC.