Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Supplemental oxygen provides no beneficial effect on 1-year mortality

30 Sep 2017

Routine use of supplemental oxygen does not appear to cut 1-year all-cause mortality in patients with suspected myocardial infarction (MI) but who do not have hypoxaemia, a study has shown.

A total of 6,629 patients with suspected MI and an oxygen saturation of ≥90 percent were randomized to receive either supplemental oxygen (6 litres/minute for 6 to 12 hours, delivered through an open face mask) or ambient air.

The primary outcome was death from any cause within 365 days after randomization. Secondary endpoints included death from any cause within 30 days after randomization, rehospitalization with MI, rehospitalization with heart failure, cardiovascular death, as well as composites of these endpoints, assessed at 30 and 365 days.

Median duration of oxygen therapy was 11.6 hours. At the end of the treatment period, median oxygen saturation was 99 percent in the oxygen therapy arm vs 97 percent in the ambient air arm (p<0.001). Hypoxaemia occurred with greater frequency among patients given ambient air than among those who received supplemental oxygen (62 vs 254 patients; p<0.001). The median of the highest troponin level observed during hospitalization was 946.5 ng/litre in the oxygen arm vs 983.0 ng/litre in the ambient-air arm.

In Cox proportional hazards model, the primary outcome of death from any cause within 1 year of randomization did not significantly differ between the oxygen and ambient-air arms (5.0 vs 5.1 percent, respectively; hazard ratio [HR], 0.97; 95 percent CI, 0.79 to 1.21; p=0.80).

Likewise, the number of patients who were rehospitalized for MI within 1 year was similar between the two treatment arms (3.8 vs 3.3 percent; HR, 1.13; 0.88 to 1.46; P=0.33). The results were consistent across all predefined subgroups, including infarction type, sex, age, smoking status and presence of diabetes, among others.

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Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.