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Tristan Manalac, Yesterday
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Supervised workouts mitigate risk of diabetes in pregnancy

24 Nov 2020

Undergoing in-facility physical activity (PA) programmes initiated before the 20th week of gestation helps reduce the risk of developing gestational diabetes mellitus (GDM) among high-risk mothers, according to the results of a meta-analysis.

The meta-analysis included 11 trials evaluating PA interventions in relation to the risk of GDM. These studies involved pregnant women who were overweight or obese, with prior GDM or macrosomia, or high-risk status on a GDM risk assessment tool. The total population comprised 1,467 participants.

One trial was from Asia, three from Oceania, three from Europe, and four from North America. Five trials conducted a supervised PA intervention in a healthcare facility, while the other six were delivered outside of a healthcare facility. Recruitment was held prior to the 16th gestational week in seven studies and up to 20 weeks in four studies, with the intervention continuing up to approximately 36 weeks across all of them. All studies provided participants with pregnancy-specific dietary advice as per local guidelines.

Pooled data revealed that compared with usual care, PA significantly lowered the risk of GDM, but only when it was delivered in a healthcare facility (risk ratio [RR], 0.53, 95 percent confidence interval [CI], 0.38–0.74).

The number needed to treat with PA in pregnancy to prevent one GDM event was 18 (95 percent CI, 14 – 29).

More studies are needed to compare PA in-facility vs outside a healthcare facility to pinpoint the determinants of its success in GDM prevention.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.