Most Read Articles
19 Sep 2016
Sertraline may prevent the onset of depressive disorders after traumatic brain injury (TBI), a randomized trial showed.
Tristan Manalac, 17 Aug 2019
Daily engagement in brief, self-guided mindfulness and relaxation practices eases symptoms of borderline personality disorder in young adults, according to a recent Singapore study.
09 Oct 2016
The use of hormonal contraception increases the risk of subsequent use of antidepressants and a first diagnosis of depression, results of a study show.
01 Dec 2016
Vortioxetine 5-20 mg/day lessens depression and anxiety severity in patients with major depressive disorder (MDD) and high levels of anxiety, as observed in a meta-analysis of 10 randomised, placebo-controlled, 6/8-week trials.

Suicide more common in patients with digestive system cancers

06 Sep 2018
A day may come when a pill can be taken to prevent suicide, borne from the partnership between University of Utah and pharmaceutical giant, Janssen in researching biomarkers related to suicidal tendencies.

Suicide appears to be more common in patients with cancers of the digestive system, especially in those with pancreatic and oesophageal cancers, a recent study has found.

The analysis included 856,293 patients with digestive system cancers (54.4 percent male), in whom 881 suicide cases were reported over a mean follow-up duration of 3.14 years. The resulting suicide rate was 32.77 per 100,000 person-years, which was almost twice that in the general US population (standardized mortality ratio [SMR], 1.91; 95 percent CI, 1.79–2.04).

Colon cancer was observed in 37 percent of the cohort and was the most common digestive system cancer subtype. This was followed by cancers of the rectum and rectosigmoid junction (16 percent), and pancreatic cancer (14 percent). Oesophageal cancer was the least common subtype (5.1 percent).

Disaggregation of the analysis by cancer site showed that suicide rates were consistently elevated relative to the general population.

Notably, despite being the least common type, oesophageal cancer had one of the highest relative suicide risks (SMR, 5.03; 4.03–6.19), second only to pancreatic cancer (SMR, 5.28; 4.26–6.47). The corresponding absolute rates were 116.54 and 86.04 suicides per 100,000 person-years.

Cancers of the stomach (SMR, 2.84; 2.26–3.53) and of the liver and intrahepatic bile duct (SMR, 2.14; 1.58–2.85) also resulted in suicide rates that were more than double than in the general population.

In contrast, colon (SMR, 1.36; 1.22–1.52) and rectum and rectosigmoid junction (SMR, 1.65; 1.42–1.90) cancers had the lowest suicide rates of all the subtypes, though these were still significantly higher than in the general population.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Psychiatry - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
19 Sep 2016
Sertraline may prevent the onset of depressive disorders after traumatic brain injury (TBI), a randomized trial showed.
Tristan Manalac, 17 Aug 2019
Daily engagement in brief, self-guided mindfulness and relaxation practices eases symptoms of borderline personality disorder in young adults, according to a recent Singapore study.
09 Oct 2016
The use of hormonal contraception increases the risk of subsequent use of antidepressants and a first diagnosis of depression, results of a study show.
01 Dec 2016
Vortioxetine 5-20 mg/day lessens depression and anxiety severity in patients with major depressive disorder (MDD) and high levels of anxiety, as observed in a meta-analysis of 10 randomised, placebo-controlled, 6/8-week trials.