Most Read Articles
18 Jun 2019
The aromatase inhibitor anastrozole shows promise in the treatment of children with congenital adrenal hyperplasia, reducing bone age advancement without adversely affecting bone mineral density and visceral adipose tissue, as shown in a recent study.
20 hours ago
Monotherapy with tenofovir disoproxil fumarate increases virologic response for up to 240 weeks in pretreated patients with hepatitis B virus infection (HBV) who are resistant to entecavir and/or adefovir, a new study has found.
Elvira Manzano, Yesterday
Long-term treatment with the interleukin-5 receptor alpha-directed cytolytic monoclonal antibody benralizumab led to long-term control of asthma, improvement in pulmonary function, and was safe in patients with severe eosinophilic asthma in the 2-year integrated analysis of the SIROCCO, CALIMA, and ZONDA pivotal studies plus the BORA extension study reported at ATS 2019.
Pearl Toh, Yesterday
Emerging evidence is showing that the two major new classes of antidiabetic drugs — SGLT2* inhibitors and GLP-1** receptor agonists (RAs) — not only confer cardiovascular (CV) benefits to patients with type 2 diabetes (T2D), they also delay the loss of kidney function among these patients, potentially providing nephrologists with an additional tool in their armamentarium for managing patients with chronic kidney disease (CKD) in the future.

Suicide more common in patients with digestive system cancers

06 Sep 2018
A day may come when a pill can be taken to prevent suicide, borne from the partnership between University of Utah and pharmaceutical giant, Janssen in researching biomarkers related to suicidal tendencies.

Suicide appears to be more common in patients with cancers of the digestive system, especially in those with pancreatic and oesophageal cancers, a recent study has found.

The analysis included 856,293 patients with digestive system cancers (54.4 percent male), in whom 881 suicide cases were reported over a mean follow-up duration of 3.14 years. The resulting suicide rate was 32.77 per 100,000 person-years, which was almost twice that in the general US population (standardized mortality ratio [SMR], 1.91; 95 percent CI, 1.79–2.04).

Colon cancer was observed in 37 percent of the cohort and was the most common digestive system cancer subtype. This was followed by cancers of the rectum and rectosigmoid junction (16 percent), and pancreatic cancer (14 percent). Oesophageal cancer was the least common subtype (5.1 percent).

Disaggregation of the analysis by cancer site showed that suicide rates were consistently elevated relative to the general population.

Notably, despite being the least common type, oesophageal cancer had one of the highest relative suicide risks (SMR, 5.03; 4.03–6.19), second only to pancreatic cancer (SMR, 5.28; 4.26–6.47). The corresponding absolute rates were 116.54 and 86.04 suicides per 100,000 person-years.

Cancers of the stomach (SMR, 2.84; 2.26–3.53) and of the liver and intrahepatic bile duct (SMR, 2.14; 1.58–2.85) also resulted in suicide rates that were more than double than in the general population.

In contrast, colon (SMR, 1.36; 1.22–1.52) and rectum and rectosigmoid junction (SMR, 1.65; 1.42–1.90) cancers had the lowest suicide rates of all the subtypes, though these were still significantly higher than in the general population.

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Most Read Articles
18 Jun 2019
The aromatase inhibitor anastrozole shows promise in the treatment of children with congenital adrenal hyperplasia, reducing bone age advancement without adversely affecting bone mineral density and visceral adipose tissue, as shown in a recent study.
20 hours ago
Monotherapy with tenofovir disoproxil fumarate increases virologic response for up to 240 weeks in pretreated patients with hepatitis B virus infection (HBV) who are resistant to entecavir and/or adefovir, a new study has found.
Elvira Manzano, Yesterday
Long-term treatment with the interleukin-5 receptor alpha-directed cytolytic monoclonal antibody benralizumab led to long-term control of asthma, improvement in pulmonary function, and was safe in patients with severe eosinophilic asthma in the 2-year integrated analysis of the SIROCCO, CALIMA, and ZONDA pivotal studies plus the BORA extension study reported at ATS 2019.
Pearl Toh, Yesterday
Emerging evidence is showing that the two major new classes of antidiabetic drugs — SGLT2* inhibitors and GLP-1** receptor agonists (RAs) — not only confer cardiovascular (CV) benefits to patients with type 2 diabetes (T2D), they also delay the loss of kidney function among these patients, potentially providing nephrologists with an additional tool in their armamentarium for managing patients with chronic kidney disease (CKD) in the future.