Most Read Articles
Tristan Manalac, 01 Mar 2019
Poor diet quality appears to impair mental health, according to a new study.
05 Mar 2019
Obesity and allergic disease increase the risk of mental health problems in adolescents, a recent Korea study has found.
Tristan Manalac, 15 Mar 2019
Neither multinutrient supplementation nor food-related behavioural activation therapy appear to protect against major depressive disorder (MDD) episodes in overweight or obese adults with subsyndromal depressive symptoms, according to a recent study.
11 Apr 2019
Cannabis use disorder appears to exert a beneficial effect on the risk of disorders of gut–brain interaction and inflammatory bowel disease in patients with schizophrenia but not in population controls, a study has found. This finding raises the possibility of new targets for treatment and prevention of digestive organ disorders in schizophrenia.

Suicide more common in patients with digestive system cancers

06 Sep 2018
A day may come when a pill can be taken to prevent suicide, borne from the partnership between University of Utah and pharmaceutical giant, Janssen in researching biomarkers related to suicidal tendencies.

Suicide appears to be more common in patients with cancers of the digestive system, especially in those with pancreatic and oesophageal cancers, a recent study has found.

The analysis included 856,293 patients with digestive system cancers (54.4 percent male), in whom 881 suicide cases were reported over a mean follow-up duration of 3.14 years. The resulting suicide rate was 32.77 per 100,000 person-years, which was almost twice that in the general US population (standardized mortality ratio [SMR], 1.91; 95 percent CI, 1.79–2.04).

Colon cancer was observed in 37 percent of the cohort and was the most common digestive system cancer subtype. This was followed by cancers of the rectum and rectosigmoid junction (16 percent), and pancreatic cancer (14 percent). Oesophageal cancer was the least common subtype (5.1 percent).

Disaggregation of the analysis by cancer site showed that suicide rates were consistently elevated relative to the general population.

Notably, despite being the least common type, oesophageal cancer had one of the highest relative suicide risks (SMR, 5.03; 4.03–6.19), second only to pancreatic cancer (SMR, 5.28; 4.26–6.47). The corresponding absolute rates were 116.54 and 86.04 suicides per 100,000 person-years.

Cancers of the stomach (SMR, 2.84; 2.26–3.53) and of the liver and intrahepatic bile duct (SMR, 2.14; 1.58–2.85) also resulted in suicide rates that were more than double than in the general population.

In contrast, colon (SMR, 1.36; 1.22–1.52) and rectum and rectosigmoid junction (SMR, 1.65; 1.42–1.90) cancers had the lowest suicide rates of all the subtypes, though these were still significantly higher than in the general population.

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Most Read Articles
Tristan Manalac, 01 Mar 2019
Poor diet quality appears to impair mental health, according to a new study.
05 Mar 2019
Obesity and allergic disease increase the risk of mental health problems in adolescents, a recent Korea study has found.
Tristan Manalac, 15 Mar 2019
Neither multinutrient supplementation nor food-related behavioural activation therapy appear to protect against major depressive disorder (MDD) episodes in overweight or obese adults with subsyndromal depressive symptoms, according to a recent study.
11 Apr 2019
Cannabis use disorder appears to exert a beneficial effect on the risk of disorders of gut–brain interaction and inflammatory bowel disease in patients with schizophrenia but not in population controls, a study has found. This finding raises the possibility of new targets for treatment and prevention of digestive organ disorders in schizophrenia.