Most Read Articles
Roshini Claire Anthony, 4 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Elvira Manzano, 5 days ago
Treatment with two investigational, oral JAK inhibitors may be beneficial in individuals with moderate‐to‐severe alopecia areata (spot baldness), an autoimmune disease that can cause a lot of anxiety, according to an ongoing phase II study.
3 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.

Suicide more common in patients with digestive system cancers

06 Sep 2018
A day may come when a pill can be taken to prevent suicide, borne from the partnership between University of Utah and pharmaceutical giant, Janssen in researching biomarkers related to suicidal tendencies.

Suicide appears to be more common in patients with cancers of the digestive system, especially in those with pancreatic and oesophageal cancers, a recent study has found.

The analysis included 856,293 patients with digestive system cancers (54.4 percent male), in whom 881 suicide cases were reported over a mean follow-up duration of 3.14 years. The resulting suicide rate was 32.77 per 100,000 person-years, which was almost twice that in the general US population (standardized mortality ratio [SMR], 1.91; 95 percent CI, 1.79–2.04).

Colon cancer was observed in 37 percent of the cohort and was the most common digestive system cancer subtype. This was followed by cancers of the rectum and rectosigmoid junction (16 percent), and pancreatic cancer (14 percent). Oesophageal cancer was the least common subtype (5.1 percent).

Disaggregation of the analysis by cancer site showed that suicide rates were consistently elevated relative to the general population.

Notably, despite being the least common type, oesophageal cancer had one of the highest relative suicide risks (SMR, 5.03; 4.03–6.19), second only to pancreatic cancer (SMR, 5.28; 4.26–6.47). The corresponding absolute rates were 116.54 and 86.04 suicides per 100,000 person-years.

Cancers of the stomach (SMR, 2.84; 2.26–3.53) and of the liver and intrahepatic bile duct (SMR, 2.14; 1.58–2.85) also resulted in suicide rates that were more than double than in the general population.

In contrast, colon (SMR, 1.36; 1.22–1.52) and rectum and rectosigmoid junction (SMR, 1.65; 1.42–1.90) cancers had the lowest suicide rates of all the subtypes, though these were still significantly higher than in the general population.

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Most Read Articles
Roshini Claire Anthony, 4 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Elvira Manzano, 5 days ago
Treatment with two investigational, oral JAK inhibitors may be beneficial in individuals with moderate‐to‐severe alopecia areata (spot baldness), an autoimmune disease that can cause a lot of anxiety, according to an ongoing phase II study.
3 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.