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Sugar-sweetened beverage intake tied to concentrations of circulating ceramides

23 Feb 2020

Higher concentrations of distinct ceramide species, known to be linked to adverse metabolic health, are associated with cumulative sugar-sweetened beverage (SSB) consumption that contributes to the development of cardiometabolic diseases, suggests a study.

Participants from the Framingham Heart Study’s Offspring Cohort who had three ceramides measured (n=1,561; mean age, 66 years; 59 percent women) were included in this study. SSB consumption was measured four times over 14 years.

The authors categorized the participants according to cumulative SSB intake: nonconsumers (0 to <1 SSB serving/mo) and occasional (1 SSB serving/mo to <1 serving/wk), frequent (1 SSB serving/wk to <1 serving/d), and daily (≥ SSB serving/d) consumers.

Multivariable linear regression models were generated to assess the association of cumulative SSB consumption (independent variable) with blood concentrations of ceramides (C16:0, C22:0 and C24:0) and ceramide ratios (C22:0/C16:0 and C24:0/C16:0).

Adjusted models showed a positive association of more frequent cumulative SSB intake with concentrations of the C16:0 and C22:0 ceramides (ptrend<0.05). Daily consumers had higher mean concentrations of the C16:0 (0.01 μg/mL, 95 percent confidence interval [CI], 0.002–0.017 µg/mL) and C22:0 ceramides (0.06 µg/mL, 95 percent CI, 0.018–0.092 µg/mL) than nonconsumers.

Results persisted when modeling continuous cumulative SSB consumption per 1 serving/d.

Effect modification by diabetes status was noted in the association between cumulative SSB consumption and concentrations of the C24:0 ceramide (pinteraction=0.014). Stratified analysis further revealed a positive correlation between more frequent cumulative SSB intake and concentrations of the C24:0 ceramide only in individuals with prediabetes or diabetes (ptrend=0.001).

“Ceramides have been implicated in the pathogenesis of type 2 diabetes and cardiovascular disease,” the authors said.

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Most Read Articles
01 Apr 2020
Being overweight or obese in adolescence appears to increase the risk of papillary thyroid cancer in adulthood, a recent study has shown.
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
01 Apr 2020
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).