Most Read Articles
01 Jun 2015
New drug applications approved by US FDA as of 15 – 31 May 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
22 May 2017
Consumption of glutinous brown rice (GBR) controls the whole-day glucose profile of patients with type 2 diabetes mellitus (T2DM), mainly by lowering postprandial glucose excursion, reports a study. In addition, GBR is preferred over nonglutinous brown rice (BR) in terms of palatability.
10 Oct 2016
Use of dipeptidyl peptidase-4 (DPP-4) inhibitors may reduce the risk of mortality and the combination of myocardial infarction and ischaemic stroke in type 2 diabetes (T2D), without increasing the risk of hospitalisation for heart failure even in T2D patients with pre-existing HF, a nationwide cohort study from Taiwan suggests.

Sucralose exposure common in healthy young adults

20 Apr 2017

Instructions to avoid low-calorie sweeteners (LCSs) are ineffective, according to a study, adding that nondietary sources such as personal care products may significantly contribute to overall exposure.

Researchers enrolled a total of 18 healthy “nonconsumers” (<1 food or beverage with LCSs/mo; aged 18 to 35 years) in a 2-week trial that assessed the effects of LCSs on the gut microbiota and consisted of three visits.

Participants were advised extensively about avoiding LCSs at baseline. After the run-in, they were randomized to consume diet soda containing sucralose or carbonated water (control) three times per day for 1 week. Participants kept food diaries throughout the study, and a spot urine sample was taken at each visit.

“Despite the selection of healthy volunteers with minimal reported LCS consumption, more than one-third were exposed to sucralose at baseline and/or before randomization, and nearly half were exposed after assignment to the control,” researchers said.

There were eight participants who had sucralose in their urine (29.9 to 239.0 ng/mL; mean 111.4 ng/mL) at baseline. After the run-in, sucralose was detected in eight individuals, two of whom did not have detectable sucralose at baseline (25.0 to 1,062.0 ng/mL; mean 191.7 ng/mL). Only one participant reported consuming an LCS-containing food prior to her visit.

After the intervention, sucralose was found in three individuals randomized to receive carbonated water (26 to 121 ng/mL; mean 60.7 ng/mL).

LCSs are found in many foods and beverages, but consumers may not be aware of their presence. Also, the role of LCSs in appetite, weight and health remains controversial, according to researchers.

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Most Read Articles
01 Jun 2015
New drug applications approved by US FDA as of 15 – 31 May 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
22 May 2017
Consumption of glutinous brown rice (GBR) controls the whole-day glucose profile of patients with type 2 diabetes mellitus (T2DM), mainly by lowering postprandial glucose excursion, reports a study. In addition, GBR is preferred over nonglutinous brown rice (BR) in terms of palatability.
10 Oct 2016
Use of dipeptidyl peptidase-4 (DPP-4) inhibitors may reduce the risk of mortality and the combination of myocardial infarction and ischaemic stroke in type 2 diabetes (T2D), without increasing the risk of hospitalisation for heart failure even in T2D patients with pre-existing HF, a nationwide cohort study from Taiwan suggests.