Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Substituting sucrose, fructose with starch lowers LDL-C concentrations

10 Jan 2020
There are many much beloved sources of carbohydrates we can taste, according to new findings

Replacing sucrose and fructose with starch results in reduced low-density lipoprotein cholesterol (LDL-C) concentrations, reveals a study. Moreover, substitution of fructose with glucose provides a beneficial effect on insulin resistance as well as uric acid concentrations.

This network meta-analysis (NMA) included randomized controlled trials (RCTs) investigating the isocaloric effect of substituting dietary sugars (fructose, glucose, sucrose) with other sugars or starch on cardiometabolic risk markers, such as LDL-C, triacylglycerol (TG), fasting glucose (FG), glycated haemoglobin (HbA1c), insulin resistance (HOMA-IR), uric acid, C-reactive protein (CRP), alanine transaminase (ALT), aspartate transaminase (AST) and liver fat content.

The investigators calculated the pooled mean differences (MDs) with 95 percent confidence intervals (CIs) and ranked the surface under the cumulative ranking curves (SUCRAs) to identify the most beneficial intervention for each outcome. They also used the Confidence In Network Meta-Analysis tool to assess the certainty of evidence.

Thirty-eight RCTs, including a total of 1,383 participants, met the eligibility criteria. LDL-C concentrations decreased with interventions replacing sucrose with starch (MD, –0.23 mmol/L, 95 percent CI, –0.38 to –0.07 mmol/L) or fructose with starch (MD, –0.22 mmol/L, 95 percent CI, –0.39 to –0.05 mmol/L; SUCRAstarch, 98 percent).

Substituting sucrose with starch also reduced FG concentrations (MD, –0.14 mmol/L, 95 percent CI, –0.29 to 0.01 mmol/L; SUCRAstarch, 91 percent). In addition, the exchange of fructose with an equivalent energy amount of glucose lowered HOMA-IR (MD, –0.36, 95 percent CI, –0.71 to –0.02; SUCRAglucose, 74 percent) and uric acid (MD, –23.77, 95 percent CI, –44.21 to –3.32 µmol/L; SUCRAglucose, 93 percent).

No significant effects were noted for TG, HbA1c, CRP, ALT and AST, according to the investigators, adding that the study was limited by its very low-to-moderate certainty of evidence.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.