Most Read Articles
2 days ago
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 13 Apr 2018
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Pearl Toh, 12 Apr 2018
A smartwatch photoplethysmography coupled with a mobile application using a machine learning algorithm can passively and accurately detect atrial fibrillation (AF) in patients undergoing cardioversion, albeit with less accuracy in ambulatory individuals with self-reported AF, a proof-of-concept study shows.
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Impaired endothelial-dependent microvascular reactivity appears to be predictive of albuminuria progression in Asian patients with type 2 diabetes (T2D) who have normal urine albumin levels at baseline, but not in those with microalbuminuria, a prospective longitudinal cohort study suggests.

Subcutaneous secukinumab prevents radiographic progression in psoriatic arthritis

10 Apr 2018

Treatment with subcutaneous secukinumab leads to significant inhibition of radiographic progression and improvement of clinical signs and symptoms in patients with psoriatic arthritis (PsA), according to the results of the FUTURE 5 study.

The phase III study randomly assigned 996 adult patients (mean age 48.8 years; 49.8 percent female; mean time since PsA diagnosis, 6.6 years) to the following treatment arms: secukinumab 300 mg with loading dose (LD; n=222), secukinumab 150 mg with LD (n=220), secukinumab 150 mg without LD (n=222) or placebo (n=332). Treatment was administered at baseline, weeks 1, 2 and 3, and then every 4 weeks from week 4.

At week 16, the primary endpoint of the proportion of patients achieving an American College of Rheumatology 20 (ACR20) response was significantly greater in all secukinumab arms than in the placebo arm (62.6 percent in the 300-mg group, 55.5 percent in the 150 mg with LD group and 59.5 percent in the 150 mg without LD group vs 27.4 percent; p<0.0001 for all).

At week 24, radiographic progression, as measured by van der Heijde-modified total Sharp score, was significantly inhibited in all secukinumab arms vs placebo arm (p<0.01 for 300 mg with LD and 150 mg without LD; p<0.05 for 150 mg with LD).

Adverse event rates at week 24 were comparable across treatment arms: 63.1 percent for 300 mg with LD, 62.7 percent for 150 mg with LD, 61.1 percent for 150 mg without LD, and 62.0 percent for placebo. There were no reports of deaths or new safety signals.

FUTURE 5 demonstrates the efficacy of subcutaneous secukinumab 300 mg and 150 mg, as well as the benefit of an LD regimen (regardless of the dose) especially when aiming for higher levels of response and faster outcomes in joint and skin endpoints, in the treatment of PsA, researchers said.

Moreover, the present data confirm and extend the results of previous studies demonstrating the therapeutic potential of secukinumab in achieving comprehensive treatment goals in PsA, they added.

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Most Read Articles
2 days ago
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 13 Apr 2018
Taking 10 resting blood pressure (BP) readings daily for 2 days provides a reliable, stable representation of patients’ resting systolic (S)BP and diastolic (D)BP, according to a study. This approach shows that the current home BP monitoring protocol of twice-daily readings for 4–7 days may be trimmed down to just 48 hours.
Pearl Toh, 12 Apr 2018
A smartwatch photoplethysmography coupled with a mobile application using a machine learning algorithm can passively and accurately detect atrial fibrillation (AF) in patients undergoing cardioversion, albeit with less accuracy in ambulatory individuals with self-reported AF, a proof-of-concept study shows.
Pearl Toh, 13 Apr 2018
Impaired endothelial-dependent microvascular reactivity appears to be predictive of albuminuria progression in Asian patients with type 2 diabetes (T2D) who have normal urine albumin levels at baseline, but not in those with microalbuminuria, a prospective longitudinal cohort study suggests.