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Subcutaneous fat index holds prognostic value in castration-resistant prostate cancer

12 Feb 2018

Subcutaneous fat index (SFI) shows utility in predicting survival in castration-resistant prostate cancer (CRPC), according to a study. Specifically, patients with higher SFI appear to have higher rates of radiographic progression-free survival (RFS) and cancer-specific survival (CSS) than those with lower SFI.

Researchers examined the medical records of 282 consecutive patients who were diagnosed with CRPC between 2009 and 2017. SFI, visceral fat index and skeletal muscle index at CRPC diagnosis were determined using computed tomography data.

Survival analyses for all body composition parameters, which were dichotomized at 39.9 cm2/m2 (SFI), 58 cm2/m2 (visceral fat index) and 52.4 cm2/m2 (skeletal muscle index).

Independent predictors of CSS at CRPC diagnosis included prostate-specific antigen levels, Gleason score ≥8, performance status, shorter period from androgen-deprivation therapy to CRPC and SFI <39.9 cm2/m2.

During the median follow-up of 16.0 months, the number of docetaxel cycles were higher in patients with SFI ≥39.9 cm2/m2 than in those with SFI <39.9 cm2/m2. More importantly, patients with higher SFI had more favourable 1-year RFS (p=0.009) and 2-year CSS (p=0.021).

The present data show that SFI determined via computed tomography data may be used as a useful objective prognostic factor for discussing therapeutic options for CRPC patients, researchers said.

However, more work is needed to define the roles of each body composition parameter in relation to pharmacokinetics and oncological outcome in CRPC, they added.

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Most Read Articles
2 days ago
No association exists between physical activity and the risk of urological cancer, according to a population-based prospective study in Japan.
12 Feb 2019
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
3 days ago
Patients with childhood-onset inflammatory bowel disease are more likely to die than the general population, a study suggests.
3 days ago
Reduced caloric intake results in a significant improvement in glucose metabolism and body-fat composition, including liver-fat content, according to a study. Changes in ferritin levels appear to mediate the striking reduction in liver fat.