Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.

Subcutaneous adipose tissue index predicts mortality in cirrhotic females

20 Aug 2018
The obesity epidemic hits Malaysia hard with cardiovascular disease occurring during younger ages.

Female patients with cirrhosis who have low subcutaneous adipose tissue index (SATI) scores are at a higher risk of mortality, a recent study has found.

Researchers analysed 677 computer tomography images taken at the 3rd lumbar vertebra. Three body composition indices were obtained: SATI, visceral adipose tissue index and skeletal muscle index (SMI). Cox proportional and competing-risk analysis hazard models were used to determine the relationship between the measured indices and mortality risk.

The study sample was predominantly male (67 percent) with an average age of 57±7 years. Males tended to have elevated SMI (53±12 v 45±9 cm2/m2) while females had higher SATI (67±52 vs 48±36 cm2/m2; p<0.001 for both). Body mass index was comparable between the sexes.

Multivariate analysis showed that in female patients with ascites, SATI <60 cm2/m2 was significantly associated with higher mortality relative to those with high SATI (hazard ratio [HR], 2.06; 95 percent CI, 1.08–3.91; p=0.03) and was independently predictive of mortality (area under the curve [AUC], 0.64; 0.56–0.71; p<0.001).

Using 60 cm2/m2 as a threshold, researchers further showed that the 6-month, 1-year, 2-year and 5-year probabilities of survival in females with low SATI were 71 percent, 64 percent, 52 percent and 36 percent, respectively. The corresponding values in patients with high SATI were 84 percent, 78 percent, 70 percent and 61 percent.

In comparison, SMI (HR, 0.98; 0.96–1.00; p=0.02) but not SATI was a predictor of mortality in males.

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Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.