Most Read Articles
19 Sep 2016
Sertraline may prevent the onset of depressive disorders after traumatic brain injury (TBI), a randomized trial showed.
Tristan Manalac, 6 days ago
Daily engagement in brief, self-guided mindfulness and relaxation practices eases symptoms of borderline personality disorder in young adults, according to a recent Singapore study.
09 Oct 2016
The use of hormonal contraception increases the risk of subsequent use of antidepressants and a first diagnosis of depression, results of a study show.
01 Dec 2016
Vortioxetine 5-20 mg/day lessens depression and anxiety severity in patients with major depressive disorder (MDD) and high levels of anxiety, as observed in a meta-analysis of 10 randomised, placebo-controlled, 6/8-week trials.

Subcortical volume changes seen in obsessive-compulsive disorder

23 Sep 2016
A world-wide meta-analysis showed that paediatric and adult obsessive-compulsive disorder (OCD) have different patterns of subcortical abnormalities.

Previous OCD studies produced inconsistent brain imaging findings due to small sample size and clinical heterogeneity. In the present study, the investigators conducted a meta- and mega-analyses of data from OCD centers worldwide.

The study analyzed T1 images from 1,830 OCD patients and 1,759 control subjects. Coordinated and standardized processing was used for profiling subcortical brain volume changes between the two groups.

A meta-analysis was conducted on the mean left and right hemosphere measurements of each subcortical structure. Pooled volumetric measurements were used for mega-analysis.

Results of the meta-analysis showed significantly smaller hippocampal volumes and larger pallidum volumes among adult OCD patients. Both findings were more pronounced in medicated patients. Significantly larger thalamic volumes were seen in unmedicated paediatric patients. Sample characteristics did not mediate the findings. Similar findings were obtained in the mega-analysis.

These findings also suggest the importance of possible neurodevelopmental alterations in OCD based on significant subcortical abnormalities in adult and paediatric OCD.
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Most Read Articles
19 Sep 2016
Sertraline may prevent the onset of depressive disorders after traumatic brain injury (TBI), a randomized trial showed.
Tristan Manalac, 6 days ago
Daily engagement in brief, self-guided mindfulness and relaxation practices eases symptoms of borderline personality disorder in young adults, according to a recent Singapore study.
09 Oct 2016
The use of hormonal contraception increases the risk of subsequent use of antidepressants and a first diagnosis of depression, results of a study show.
01 Dec 2016
Vortioxetine 5-20 mg/day lessens depression and anxiety severity in patients with major depressive disorder (MDD) and high levels of anxiety, as observed in a meta-analysis of 10 randomised, placebo-controlled, 6/8-week trials.