Most Read Articles
13 Jul 2019
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 15 Jul 2019
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
Tristan Manalac, 2 days ago
In patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI), admission Killip classification and creatinine and troponin levels are important cardiac mortality predictors, according to a recent Singapore study.

Subcortical volume changes seen in obsessive-compulsive disorder

23 Sep 2016
A world-wide meta-analysis showed that paediatric and adult obsessive-compulsive disorder (OCD) have different patterns of subcortical abnormalities.

Previous OCD studies produced inconsistent brain imaging findings due to small sample size and clinical heterogeneity. In the present study, the investigators conducted a meta- and mega-analyses of data from OCD centers worldwide.

The study analyzed T1 images from 1,830 OCD patients and 1,759 control subjects. Coordinated and standardized processing was used for profiling subcortical brain volume changes between the two groups.

A meta-analysis was conducted on the mean left and right hemosphere measurements of each subcortical structure. Pooled volumetric measurements were used for mega-analysis.

Results of the meta-analysis showed significantly smaller hippocampal volumes and larger pallidum volumes among adult OCD patients. Both findings were more pronounced in medicated patients. Significantly larger thalamic volumes were seen in unmedicated paediatric patients. Sample characteristics did not mediate the findings. Similar findings were obtained in the mega-analysis.

These findings also suggest the importance of possible neurodevelopmental alterations in OCD based on significant subcortical abnormalities in adult and paediatric OCD.
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Most Read Articles
13 Jul 2019
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 15 Jul 2019
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
Tristan Manalac, 2 days ago
In patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI), admission Killip classification and creatinine and troponin levels are important cardiac mortality predictors, according to a recent Singapore study.