Most Read Articles
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
6 days ago
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
2 days ago
Cuff-based excess pressure (XSP) is modestly associated with carotid intima–media thickness independent of conventional risk factors, reveals a recent study.

Subbing carbs with good fats during midlife may slow cognitive decline in silver years

Pearl Toh
14 Jan 2020

Higher intake of plant-based fat, in particular n-6 polyunsaturated fatty acids (PUFAs), in place of carbohydrate during midlife was associated with a reduced risk of cognitive impairment in Chinese adults in later life, according to the Singapore Chinese Health Study (SCHS). 

“Mechanistic studies have indicated that FAs play important roles in brain structure and function,” said the researchers led by Dr Koh Woon-Puay from Duke-NUS Medical School, Singapore.

However, previous studies on the link between fat intake and cognitive function have yielded inconsistent results, and data from Asians were limited in particular.

“Unlike the Western dietary pattern with fat mainly derived from meat and dairy products, a major dietary source of fat in Chinese population is plant-based cooking oil,” the researchers pointed out.

The prospective cohort study included 16,736 participants aged 45–74 years (mean age 53.5 years) from the SCHS who were evaluated on their dietary pattern at baseline. They underwent cognitive function test using the Singapore modified Mini-Mental State Examination at the third follow-up visit when they were aged 61–96 years (mean age 73.2 years) — during which 2,397 participants were identified as having cognitive impairment. [J Nutr 2019;doi:10.1093/jn/nxz325]

Participants with the highest quartile of dietary total fat intake in place of total carbohydrate during midlife were less likely to have cognitive impairment when they were older compared with the lowest intake quartile (odds ratio [OR], 0.80; p-trend=0.003). However, the association was only significant for plant-based fat (OR, 0.84; p-trend=0.02), but not for animal-based fat (OR, 0.96; p-trend=0.76).

When analysing the data by the types of FAs, replacing carbohydrate with either dietary monounsaturated UFAs (MUFAs; OR, 0.80; p-trend=0.02) or PUFAs (OR, 0.84; p-trend=0.02), but not saturated FAs (SFAs; OR, 1.08; p-trend=0.51), were significantly associated with a lower risk of cognitive impairment, when comparing the highest vs the lowest intake quartiles.

Similar findings were seen when replacing SFAs with MUFAs (OR, 0.77; p-trend=0.02) or PUFAs (OR, 0.82; p-trend=0.003).

Specifically, higher intake of dietary n-6 PUFAs was significantly associated with a reduced risk of cognitive impairment, regardless of whether it was in place of carbohydrate (OR, 0.83; 95 percent confidence interval [CI], 0.70–0.98) or SFAs (OR, 0.80, 95 percent CI, 0.69–0.94). In contrast, no significant association was seen for n-3 PUFAs.

“Our study among Chinese adults indicated a lower risk of cognitive impairment with higher dietary fat intake,” said Koh and co-authors, who noted that this finding was in contrast to previous studies in Western populations. 

“One of the plausible reasons is that the consumption level was relatively moderate in our study participants compared with those reported by Western populations,” continued the researchers, who believed that the relatively moderate fat intake among Chinese may be in the optimum range, compared with the Western populations.   

The large sample size and long follow-up duration, according to the researchers, constituted major strengths of the study, unlike some studies which focused only on the elderly when cognitive function was already less amenable to improvement by dietary factors.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
6 days ago
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
2 days ago
Cuff-based excess pressure (XSP) is modestly associated with carotid intima–media thickness independent of conventional risk factors, reveals a recent study.