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Jairia Dela Cruz, 10 Apr 2019
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Jairia Dela Cruz, 30 Apr 2019
In rheumatoid arthritis (RA) patients in remission, increasing the dose interval of tocilizumab injection from the standard 162 mg once weekly to twice weekly may do more harm than good. Specifically, such a strategy is associated with a lower chance of remission maintenance as well as a lack of improvement in tolerability, as shown in a recent trial.
Jairia Dela Cruz, 29 Apr 2019
Physicians are likely to underestimate the severity of psoriatic arthritis (PsA) in patients who are older, show higher fatigue levels, complain of greater pain or have poorer mental health, according to a Singapore study. In contrast, overestimation of disease severity by physicians tends to occur in the presence of higher swollen joint counts.
Jairia Dela Cruz, 05 Jan 2017
Patients with early arthritis should be allowed to share in the decision making regarding the approach to treatment, with rheumatologists acting as the primary specialists, according to the 2016 update of the European League Against Rheumatism (EULAR) recommendations for early arthritis management.

Strong belief in medication necessity tied to better adherence in RA patients

06 Dec 2018
Adherence to the treatment regimen is a vital step to ensure illnesses are well controlled, but many patients fail to do so.

A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.

Of the 362 patients who reported taking a synthetic DMARD and/or prednisone, 14 percent and 21 percent reported poor adherence to oral DMARD or prednisone and biologics, respectively. Furthermore, 64 percent of patients reported concern about taking medicines, 81 percent about long-term effects and 47 percent about becoming too dependent on medicines.

Multivariate analyses revealed that the Beliefs about Medicines Questionnaire (BMQ) necessity score independently correlated with better adherence to oral DMARD or prednisone (adjusted odds ratio [aOR], 0.61; 95 percent CI, 0.41–0.91), whereas self-efficacy correlated with higher odds of poor adherence to oral medications (aOR, 1.23; 1.01–1.59).

On the other hand, there was no association between beliefs in medicines and self-efficacy and adherence to biologics.

“Providers can play important roles in eliciting patient beliefs about medications to improve adherence and ultimately health outcomes,” the authors said.

This study used data from a longitudinal observational cohort of persons with RA. Participants completed telephone interviews on self-reported adherence, self-efficacy, demographics and the BMQ, which evaluates beliefs in necessity and beliefs about taking medication. Bivariate and multivariate logistic regression identified associations of poor adherence to synthetic DMARD and prednisone as well as to biologic therapy, including medication concerns and necessity.

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Most Read Articles
Jairia Dela Cruz, 10 Apr 2019
Treatment with tofacitinib yields significant improvements in signs and symptoms of rheumatoid arthritis (RA) in patients from the Asia Pacific, according to data from a posthoc analysis. The drug has a safety profile consistent with global tofacitinib studies, although infections occur more frequently in Asians.
Jairia Dela Cruz, 30 Apr 2019
In rheumatoid arthritis (RA) patients in remission, increasing the dose interval of tocilizumab injection from the standard 162 mg once weekly to twice weekly may do more harm than good. Specifically, such a strategy is associated with a lower chance of remission maintenance as well as a lack of improvement in tolerability, as shown in a recent trial.
Jairia Dela Cruz, 29 Apr 2019
Physicians are likely to underestimate the severity of psoriatic arthritis (PsA) in patients who are older, show higher fatigue levels, complain of greater pain or have poorer mental health, according to a Singapore study. In contrast, overestimation of disease severity by physicians tends to occur in the presence of higher swollen joint counts.
Jairia Dela Cruz, 05 Jan 2017
Patients with early arthritis should be allowed to share in the decision making regarding the approach to treatment, with rheumatologists acting as the primary specialists, according to the 2016 update of the European League Against Rheumatism (EULAR) recommendations for early arthritis management.