Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
4 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Yesterday
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.

Stricter treatment endpoints for UC lower risk of relapse

28 Oct 2020

Ulcerative colitis (UC) patients who satisfy a more rigorous definition of disease remission are less likely to relapse, reports a new meta-analysis.

A systematic review of online databases resulted in 31 studies eligible for quantitative analysis. The researchers selected cohort studies reporting on adults whose UC was in endoscopic remission. Only reports that had a minimum 12-month risk of clinical relapse using the Mayo endoscopy subscore (MES) and/or histological disease activity were eligible.

Pooled analysis of 17 studies (n=2,608) showed that UC patients in clinical remission who achieved endoscopic remission (MES score 0) had a 52-percent lower likelihood of clinical remission than those still showing mild endoscopic activity (MES score 1; relative risk [RR], 0.48, 95 percent confidence interval [CI], 0.37–0.62).

Eight studies further showed that patients who still had mild endoscopic activity carried a median 12-month risk of clinical relapse of 28.7 percent. In comparison, the estimated annual risk for those in endoscopic remission was 13.7 percent.

Similarly, more rigorous histological definition corresponded with lower levels of relapse. In a pooled analysis of 20 studies, including 2,265 UC patients in clinical remission and endoscopic healing, those in histological remission saw a 61-percent lower risk of clinical relapse than counterparts with persistent histologic activity.

Achieving both endoscopic and histologic remission further reduced the calculated annual risk of clinical relapse from 13.7 percent (for endoscopic remission alone) to 5.0 percent.

The stricter “endpoints may be considered as preferred treatment targets, but future studies are needed to evaluate the population-level feasibility and cost-effectiveness of treating patients with UC to these endpoints,” the researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Gastroenterology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
4 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Yesterday
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.