Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Audrey Abella, 6 days ago
A pilot telemedicine initiative may be an alternative for facilitating delivery of intravenous iron (IVI) for individuals requiring iron supplementation.

Stricter treatment endpoints for UC lower risk of relapse

28 Oct 2020

Ulcerative colitis (UC) patients who satisfy a more rigorous definition of disease remission are less likely to relapse, reports a new meta-analysis.

A systematic review of online databases resulted in 31 studies eligible for quantitative analysis. The researchers selected cohort studies reporting on adults whose UC was in endoscopic remission. Only reports that had a minimum 12-month risk of clinical relapse using the Mayo endoscopy subscore (MES) and/or histological disease activity were eligible.

Pooled analysis of 17 studies (n=2,608) showed that UC patients in clinical remission who achieved endoscopic remission (MES score 0) had a 52-percent lower likelihood of clinical remission than those still showing mild endoscopic activity (MES score 1; relative risk [RR], 0.48, 95 percent confidence interval [CI], 0.37–0.62).

Eight studies further showed that patients who still had mild endoscopic activity carried a median 12-month risk of clinical relapse of 28.7 percent. In comparison, the estimated annual risk for those in endoscopic remission was 13.7 percent.

Similarly, more rigorous histological definition corresponded with lower levels of relapse. In a pooled analysis of 20 studies, including 2,265 UC patients in clinical remission and endoscopic healing, those in histological remission saw a 61-percent lower risk of clinical relapse than counterparts with persistent histologic activity.

Achieving both endoscopic and histologic remission further reduced the calculated annual risk of clinical relapse from 13.7 percent (for endoscopic remission alone) to 5.0 percent.

The stricter “endpoints may be considered as preferred treatment targets, but future studies are needed to evaluate the population-level feasibility and cost-effectiveness of treating patients with UC to these endpoints,” the researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Gastroenterology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Audrey Abella, 6 days ago
A pilot telemedicine initiative may be an alternative for facilitating delivery of intravenous iron (IVI) for individuals requiring iron supplementation.